Tourette's Syndrome - Medical Cannabis Research Papers Worldwide - 2000- 2017


Tourette's Syndrome - Medical Cannabis Research Papers Worldwide - 2000- 2017


1 Treatment of Tourette's syndrome using d9-THC. Muller-Vahl 1999. American Journal of Psychiatry 156: 495.

This is the first article documenting the successful treatment of Tourette’s syndrome with d9THC. For the first time, patients’ subjective experiences when inhaling cannabis were confirmed using a valid and reliable rating scale and also by excluding the fact  is an illegal drug.  Our findings give evidence that the beneficial effects of cannabis may be due to the most psychoactive ingredient- d9-THC. So far, it is unclear whether beneficial effects are caused by unspecific mechanisms like reduction of anxiety, sedation, or placebo effects. We speculate, however, that there could be be an interaction between d9-THC and specific cannabinoid receptors located in the basal ganglia. We plan to confirm these preliminary findings in a double blind, placebo-controlled, crossover experiment.

2 Treatment of Tourette's syndrome using d9-THC (THC): a randomized crossover trial. Muller-Vahl 2002. Pharmacopsychiatry 35: 57 to 61.

Results obtained from this pilot investigation suggest that a single-dose treatment with Delta(9)-THC is efficacious and safe in treating tics and OCB in Tourette's syndrome. It can be speculated that clinical effects may be caused by 11-OH-THC. A more long-term investigation is required to confirm these findings.

3 Influence of treatment of Tourette syndrome using delta9-tetrahydrocannabinol (d9-THC) on neuropsychological performance. Muller-Vahl 2001. Pharmacopsychiatry 34: 19 to 24. Muller-Vahl 2002. op. cit.

We suggest that the increase in phobia and anxiety is mainly due to a single-dose treatment, ruling out the possibility of administering the dosage slowly. In contrast to findings obtained from healthy cannabis users, a single-dose treatment with d9THC in patients suffering from Tourette syndrome does not reduce cognitive impairment. Therefore we suggest that further investigations should focus on the effects of a longer term therapy of Tourette's syndrome with the cannabinoid d9-THC.

4 d9-THC  is efficacious in the treatment of tics in Tourette syndrome: a six-week randomized trial. Muller-Vahl 2003. Journal of Clinical Psychiatry 64: 459 to 65.

Our findings provide more evidence that THC is an effective and safe treatment of tics. Therefore, it can be hypothesized that the central cannabinoid receptor system might play a role in Tourette's syndrome and its pathology.

5 Treatment of Tourette syndrome with d9-THC (delta 9-THC): no influence on neuropsychological performance. Muller-Vahl 2003.  Neuropsychopharmacology 28: 384 to 8.

Results from this investigation corroborates previous raw data, suggesting that in patients suffering from Tourette's respond favorably given treatment with d9THC, and it causes neither severe nor long-term cognitive deficits. Larger and longer-duration controlled studies are recommended to provide more information about  the adverse effects and profile of THC in patients suffering from Tourette's syndrome.

6 Cannabinoids reduce symptoms of Tourette's syndrome. Kirsten Mueller-Vahl. 2003. Expert Opinions in Pharmacotherapy 4: 1717 to 25.

If well-established that drugs either fail to improve tics or cause significant adverse side effects.  It is suggested that in adult patients, therapy with d9-THC should be tried. At present, it remains unclear whether herbal cannabis, different natural or synthetic cannabinoid  affect CB-1-receptor agonists or agents that interfere with the inactivation  of the body's internal endocannabinoids, and may have the best adverse effect profile seen in Tourette's syndrome.

7 Treatment of Tourette syndrome with cannabinoids. Kirsten Mueller-Vahl. 2013. Behavioral Neurology 27: 119 to 124.

THC is recommended for the treatment of Tourette's in adult patients, when first line treatments fail.   In treatment resistant adult patients, treatment with THC should be taken into consideration to alleviate tics..

8 Severe motor & vocal tics controlled with Sativex. Trainor 2016.  Australasian Psychiatry


Our findings support previous research suggesting that cannabinoids are safe and effective treatment for Tourettes and they should be considered in treatment resistant cases. Further studies are required to substantiate these findings.

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9 Tourette’s Syndrome NORML

Investigators again confirmed these preliminary findings in a randomized, double blind, placebo , crossover, single dose trial of d9THC in twelve adult Tourette's patients. Researchers report a "significant improvement of tics flux and obsessive & compulsive behavior after treatment with d9THC being compared to placebo and statistical efficacy reported.." Investigators article no cognitive impairment in subjects following d9THC administration and concluded, "THC is effective and safe in treating tics and obsessive compulsive disorder in Tourette's syndrome."

10 New York Times Blog   Search Consults   SEARCH A New Use for Medical Marijuana

This is the most comprehensive review to date on the efficacy of cannabinoids in Tourette’s.  The research comes from a research group in Britain, the Cochrane Collaboration, that reviewed all the available material and data. They found that “the improvements in tic frequency and severity were quite small and were only detected in some of the outcome measures.” The group decided that there is not enough evidence to support the use of cannabinoids in treating tics or obsessive-compulsive behavior in people with Tourette’s syndrome. (Fake news?)

11 TOURETTE SYNDROME - Cannabis Science

"Previous studies provide evidence that cannabis sativa and its d9THC( the main psychoactive ingredient of marijuana), respectively, are effective in the treatment of tics and behavioral problems in Tourette's. Therefore, it is been speculated that the central cannabinoid receptor system might be involved in Tourette's pathology. However, in healthy cannabis users, there is an longstanding debate as to whether the use of cannabis causes severe and/or long-term cognitive deficits. In this randomized double blind placebo controlled investigation, we checked out the effect of a treatment with up to 10mg d9THC over a six-week period on neuropsychological ability in twenty four patients suffering from Tourettes.

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Data was taken during medication and immediately as well as five to six weeks after withdrawal of d9THC treatment.  No detrimental effect was seen on learning curve, interference, recall and recognition of word lists, immediate visual memory span, and divided attention. Measuring immediate verbal memory span, we even found a trend towards a significant improvement during and after treatment. Results from this investigation corroborate previous results suggesting that in patients suffering from Tourette's, treatment with d9THC causes neither severe nor long-term cognitive deficits. Larger and longer duration controlled experiments are recommended to provide more data on the adverse effects / profile of d9THC in patients suffering from Tourettes."

13 The Preacher With Tourettes   The Funniest Video You Will See Today Period: Matthew Ford, The Preacher With Tourettes


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"Our results provide more evidence that THC is effective and safe in the treatment of tics." - Dr. Kirsten Müller-Vahl

Tourette's disorder features aberrant, involuntary and repetitive movements and actions.  While Tourettes is seldom dangerous to others or self harming, Tourette's is above all else, an unwelcome distraction and disruption for sufferers and their families.  Tourettes afflicts young men most, with symptoms generally lessening with......Blurting out random insults and profanity
Eye tics, blinking Repetitive movements of hands without purpose...








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