MARINOL VS CANNABIS
What is the difference between Marinol, synthetic cannabinoid, and the natural cannabis?
Marinol (dronabinol) is the only US FDA-approved synthetic cannabinoid. Marinol is produced as a gelatin capsule containing synthetic delta-9 THC in sesame oil. It is an oral medicine and is available in 2, 5, and 10mg dosages.
When medical professionals consider a drug's effectiveness, they look at look at the medicine's ability to reduce symptoms, improve vital signs in balance with negative side effects.
Toxicology is the scientific study of adverse effects in living organisms caused by chemicals. The effect of a chemical in an organism is observed and documented with mechanisms or models of action are studied, formulated and/or critiqued.
A basic premise in basic toxicology theory (and practice) is that synthetic compounds are far more likely to be toxic or assimilate into the body in a suboptimal way, often resulting in an interruption in metabolic activities, causing minor to severe poisoning.
A simple illustration is common table salt. Naturally occurring sea salts contain a mixture of sodium, potassium, magnesium and calcium salts that resembles closely blood serum and sweat concentrations. Through processing, many table salts are nearly pure sodium chloride with the trace elements removed. Elite endurance athletes use the natural sea-salt product in their sports drinks to replace minerals lost in competition. Athletes on pure sodium end up cramping and prematurely exhausted. This is a very simple, fundamental and powerful concept, that many so-called nutritionists and general practitioners to not properly comprehend.
In fact, this is the problem in taking isolates and synthetic pharmaceuticals. Thought synthetic medicines are more toxic and often less effective than naturally occurring drugs and medicines, the medical establishment pushes them for one reason and one reason only. Money. Synthetic drugs can be patented, allowing the manufacturer, a 100% monopoly on sales and profits. As synthetic drugs gradually came into the marketplace, the manufacturers began to "support research" and fund medical schools.
In time, most great natural remedies would be effectively wiped from the physician's vocabulary and knowledge set. In other words, it is a process of brainwashing. So, instead of prescribing natural whole opium for example, the pharmaceutical industry synthesizes the opiate purifies it to make their "quality" standardized product.
Clinical Data - A comparison between Marinol (dronabinol) and Cannabis.
"Marinol or Dronabinol is the INN for a pure isolated isomer of Δ9 THC, which is the dominant and psychoactive isomer found in most US grown cannabis. Orthodox medicine recognizes Marinol as a viable treatment for anorexia in people with HIV/AIDS as well as for nausea and vomiting in people undergoing chemotherapy. It is safe and effective for these uses" THC was first isolated in 1964 by Raphael Mechoulam and Yechiel Gaoni at the Weizmann Institute of Science.
Dr. Mechoulam was also one of the first scientists to discover the entourage effect, that cannabinoids and terpenes in combination are a more effective medicine, with less side effects, than isolates of monatomic strains of High THC weed with almost no other cannabinoids.
Natural and hybrid Cannabis strains have been found to contain more than hundreds of medicinal cannabinoids, including psychoactive THC, non-psychoactive CBD as well as terpenes, flavonoids, sterols and other compounds - many of which, have outstanding therapeutic benefits in their own right.
Marinol vs. Natural Plant
- Orthodox Medical Doctors new to Medical Marijuana prefer Marinol because it is a standardized medical extract. In other words, they know what's in it and believe it is easier to get a handle on simple cause and effect in therapy.
- Both Marinol and whole cannabis can effectively and safely treat many diseases and symptoms without serious side effects as compared to other medicines.
- Marinol Lacks Several of the Therapeutic Compounds including terpenes - especially the non-psychoactive cannabinoid CBD, which balances reduces anxiety in Natural Cannabis.
- Marinol gets you very high, while balanced and low THC marijuana strains do not get patients too stoned, anxious or paranoid.
- Marinol does not contain terpenes. Some terpenes have been found to enhance THC's medicinal properties while reducing or eliminating side effects of anxiety and psychosis, experienced by some.
- Cannabis can be vaporized and is prefered over the oral route by some doctors and patients.
- Marinol is in the hands of big-pharma and is more expensive than great lab tested weed.
- Patients much prefer natural cannabis to Marinol.
The position taken by CALIFORNIA NORML is that:
"Despite FDA approval2, Marinol typically provides only limited relief to select patients, particularly when compared to natural cannabis and its cannabinoids. Marinol should remain a legal option for patients and physicians; however, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic
THC the ability to use natural cannabis and its cannabinoids as a medical therapy without fear of arrest and/or criminal prosecution. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily restricted to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis."
List of Medicinal Cannabinoids not contained in Marinol.
CBG (Cannabigerol): Non-psychoactive, anti-insomnia. antimicrobial, lowers eye ball pressure
CBC (Cannabichromene): sedative that moderates the effects of THC. Pain killer, is non-psychoactive.
THCV (Tetrahydrocannabivarin): Turbo-energetic “high” effect. Appetite suppressant. euphoric, analgesic (pain relieving).
CBD (Cannabidiol): Non-psychoactive. Reduces muscle spasms, only remedy for some types of epileptic conditions . Muscle relaxant, painkiller, analgesic, antispasmodic, anxiolytic, antipsychotic, antinausea, and anti-rheumatoid arthritic properties
CBN (Cannabinol): Mildly psychoactive and non-narcotic analgesic (pain relieving).
THC works better with CBD
"Animal and human studies have shown CBD to possess anti-convulsant properties, particularly in the treatment of epilepsy.5 Natural extracts of CBD, when administered in combination with THC, significantly reduce pain, spasticity and other symptoms in multiple sclerosis (MS) patients unresponsive to standard treatment medications.6"
CBD or CBD plus THC works better than THC
"CBD was also found to be neuroprotective against glutamate neurotoxicity (i.e. stroke), cerebral infarction (localized cell death in the brain), and ethanol-induced neurotoxicity,9 with CBD being more protective against glutamate neurotoxicity than either ascorbate (vitamin C) "
The Entourage Effect
The synergy of these compounds is likely to be significantly more efficacious than oral administration of synthetic THC alone.
"Good evidence shows that secondary compounds in cannabis may enhance beneficial effects of THC. Other cannabinoid and non-cannabinoid compounds in herbal cannabis ... may reduce THC-induced anxiety, cholinergic deficits, and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity." - McPartland and Russo
"In an in vitro model of epilepsy, natural cannabis extracts performed better than THC alone. In human trials, patients suffering from multiple sclerosis experienced greater symptomatic relief from sublingual natural cannabis extracts than from the administration of oral THC."
Marinol Oral Dose is slow and erratic, Vaping MMJ is quicker and more effective
Once the game is on, it's full on. After oral administration of Marinol, patients have no choice but to experience the full psychoactive effects of the dose consumed. These dysphoric effects may last several hours.
"In practice, cannabis vaporization offers considerable advantages over oral THC consumption. While the oral ingestion of Marinol avoids the potential risks of smoking, it has significant drawbacks. Because of synthetic THC's poor bioavailability, only 5-20 percent of an oral dose ever reaches the bloodstream. The drug may not achieve peak effect until four hours after dosing."
Cannabis vaporization delivers cannabinoids to the bloodstream almost instantaneously.
Marino's therapeutic and psychoactive effects may be unpredictable and vary considerably, both from one person to another, and in the same person from one episode of use to another. By contrast.
Vaporization rapid onset also allows patients to self regulate their dosage of cannabinoids by immediately ceasing inhalation when/if their psychoactive effects become unpleasant.
Because of its rapid onset, many experienced medical professionals find that vaporized cannabis is more desirable than Marinol for patients requiring a fast-acting therapeutic agent for the sudden onset of nausea, anxiety, seizures, pain or spasms. Cannabis vaping allows patients that suffer from nausea and vomiting to receive their medicine - when they have difficulty swallowing or keeping food down. Cancer and HIV/AIDS victims often report vomiting up Marinol capsules during bouts of severe nausea.
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