HEALTH A-Z & MARIJUANA NEWS

How Women use Marijuana for Morning Sickness, What the Doctor's say.  What type is best.  Is it safe?

MORNING SICKNESS AND MARIJUANA

How Women use Marijuana for Morning Sickness, What the doctor's say. What type is best. Is it safe?

 

Cannabis or Marijuana has been used for thousands of years, even in America, where it was prescribed for more than 100 years, particularly for women's issues, cramps, PMS, pain and yes, morning sickness.  Our study did not find a single warning or note to mothers or physicians about dangerous side effects in the US Pharmacopeia (which prescribed marijuana) from 1850-1930's.  

 

Current medical studies tend to be lacking in quantity and quality; researchers often gather statistics from biased sources, such as populations that have a high incidence of drug abuse, crack, meth, heroin, opiates, prescription meds. Even so, in these negative studies, no difinitive evidence is presented that marijuana harms infants in pregnancy.  

 

The scientific studies and anecdotal evidence suggests that moderate cannabis use, both THC and CBD as well as Vitamin B6 are statistically non-toxic to mothers and infants.  With that said, there is a definite lack of clinical evidence to suggest that cannabis is entirely safe and at what consumption levels, it might be dangerous.  

 

Certainly, in mild to moderate case of morning sickness, most informed medical professionals advise against taking any quantity of drugs, cigarettes, coffee or alcohol and that would include marijuana.  However, in cases where morning sickness goes on for months, with vomiting all day long, intervention of some sort is required to avoid probable harm or even death to either the baby or the mother.

 

Pharmaceutical drugs are now in the spotlight; where many people, probably the majority, believe that the side effects are vastly underestimanted in practice, despite the warning labels.  There is an increasing number of people that believe too, that anything that is natural, a herb like marijuana for example, is a green solution, and is by definition good and without negative side effects.  The reality is that overconsumption of concentrated natural substances like alcohol (hard spirits), opium and even cannabis (dabs) could damage a fetus.

 

In this article we look at some of the science that backs up these opposing points of view.   It is rare for a woman not to experience morning sickness during pregnancy.  There is vomiting and nausea which passes naturally, but in severe cases, this condition is life threatening - for both the baby and mother. This condition of life threatening morning sickness is called Hyperemesis Gravidarum..

 

Hyperemesis Gravidarum - HG features unrelenting, excessive pregnancy-related nausea and/or vomiting that prevents adequate intake of food and fluids.  Hyperemesis Gravidarum - HG typically begins early in pregnancy, and peaks at around 20 weeks and can persist throughout the entire pregnancy.   This is where intervention is required, and now that cannabis is legal in many States, physicans are considering cannabinoid therapy as one of the safer options to treat HG.


 

” It's far beyond typical morning sickness, and it is characterized by symptoms that include the loss of greater than 5 percent of pre-pregnancy body weight - usually over 10 percent, dehydration, and production of ketones, nutritional deficiencies, metabolic imbalances, and difficulty with daily activities.”


 

As we all should know, a healthy woman can handle a few weeks morning sickness, which comes with an occasional bout of vomiting.  And so can a normal baby withstand normal morning sickness, so mother's need not press the panic button within the first few weeks.  However, if it persists, they should seek medical council and consider some form of intervention, such as medication, especially when the condition is obviously dangerous;  where the mother is vomiting a dozen times per day, for weeks on end.

 

Much of this review of the scientific and clinical evidence revealed little in the way of difinitive data about pregnancy and marijuana use.  Despite warnings to the contrary, there was little to show that marijuana was difinitively either safe nor harmful.  We foujnd that several resarch groups that were involved in clinical medical marijuana study were rookies, and generally specific education in cannabinoids: THC, the endocannabinoid system, clinical use of marijuana and so on.  Sample sizes were generally too small for useful conclustion.  Study populations tended to focus on mothers from poor areas, from families on food stamps for generations and the like.  

Then there is the question of credibility in any Federally funded study,  because Federal funding is only given when the goal is to find something negative (wrong) about marijuana.  As such,  the community now takes Federal studies with a grain or shaker full of salt.  Nonetheless, we present several Federally funded research papers here.


 

“Man, I hate puking, gives me flashbacks to being pregnant. I don't think I can ever eat bacon again.” - HG Patient


 

The most prescribed pharmaceutical preparation for morning sickness is pyridoxine -vitamin B6/doxylamine.  Natural medicine practitioners don't normally take issue with taking the naturally occurring vitamin-B6, but doxylamine, which is a synthetic antihistamine, is the object of scrutiny.  From Wiki we have:

 

``Fatalities reported doxylamine overdose. These have been characterized by coma, tonic-clonic -or grand mal seizures and cardiorespiratory arrest. Children appear to be at a high risk for cardiorespiratory arrest. A toxic dose for children of more than 1.8 mg/kg has been reported.`` - Wiki


 

SOLID SCIENCE - SOMETHING TO HANG OUR HAT ON

Because of marijuana's superior safety profile, more doctors are recommending medical marijuana, particularly in tough cases of morning sickness.

We know fairly well the lethal toxicity dose of marijuana and pharmaceutical morning sickness drugs, that is the amount that it takes to kill.   We also know pretty much that marijuana's safety profile suggests that is it safer to use than almost every pharmaceutical drug by the measure of lethal toxicity amount.   However, in pregnancy, we simply don't have a measure on the toxicity on the fetus.    From this analysis, if morning sickness requires treatment to prevent damage to the fetus, then obviously, taking the drug with the least toxicity is the best option. 


 

"Pickle juice, if you crave it or can handle it, is highly recommended, it contains all the electrolytes you lose in bouts of vomiting." - Age Old Cure Backed by Modern Science


 

Normally, people focus on weed that is high in THC, the kind that gets you stoned.  There are other kinds of marijuana phyto-drugs - plant based extracts - that have been found to work well in morning sickness: strains and concentrates with THC, CBD, THC and CBD.

 

Cannabidiol or CBD is found in high quantities in certain strain-types, sometimes accompanied by the stoning THC.  CBD is highly medicinal by itself and has that desirable, safe drug safety profile ...and it can curb nausea  while providing mild sedation.  CBD and THC have been found in the clinic to work better together than in by themselves.  This phenomena is known scientifically as the entourage effect.  
 

"That's how I got through my pregnancy. What I did was pour pickle juice into an ice tray that made mini ice cubes and when it was frozen enough to hold a toothpick, I'd stick a toothpick in each and voila! Frozen pickle juice pops that are amazing for nausea. It should be noted that we're talking about dill pickles, not sweet pickles or any other kind."



 

US PHARMACOPOEIA 1851 TO 1930

In the past, cannabis was legal in the US and was commonly prescribed for nausea and cramps, particularly as a tonic for women.  Queen Victoria was prescribed for her women's issues for example.   Back in the day, there appears to be little, if any fuss about recreational use of cannabis in Victorian England..

In addition, back in the day in America, the bulk of physicians did not agree  with the Fed that decided to make marijuana illegal.  In fact, they protested the removal of cannabis from the pharmacies, but over several years they slowly and surely complied with Fed regulations.   We're not finding records, from the 100 years of prescribing cannabis, any problems with cannabis in women's issues: specific problems in morning sickness applications, such as an increase in stillbirths and spontaneous abortion..


 

"Living through pregnancy with HG is not easy. The difficulty goes beyond the physical drain, and it becomes a mental battle to cope, stay positive, and do your best to function. When it hit me, it hit so hard. I was finding myself with nausea through the whole day and night,  and I was vomiting up to 12 times a day."



 

SOCIAL MEDIA - MEDICAL CANNABIS AND MORNING SICKNESS

Does cannabis cause problems for pregnant mothers?  As we look through the comments, there are a lot of opinions out there, many of which are not from mothers nor others lacking in professional or other experience with very bad morning sickness.  We filtered out a lot of the noise to allow a focus on what people with experience have to say.  However, we include some naysayers input, which reflect typical concerns and stereotypes, to which the editor retorts. 

 

coolTracy Lynn York  I did marijuana in 1977 my daughter was fine. But the strain of pot is man made now with chemicals. I have now been sober 19 years and I think pot should be legal everywhere. Alcohol that's the killer..

 

coolKelsey Daffin My OBGYN suggested cannabis for morning sickness. She didn't suggest smoking it, but eating it or drinking it. It works better than any of the pills they can give you, with slim to none side effects. When I dropped 15 lbs in just a few weeks because of morning sickness.  

 

coolSyndi Corkern I had severe morning sickness with all three pregnancies my girls lasted the whole pregnancy, I didn't smoke pot to ease the morning sickness, my doctor told me to drink Pepsi and ginger ale saltine crackers! I made it thru I believe your body has to be kept super healthy and clean to have a good pregnancy!

 

Editor`s note:  Such is the ignorance out there, that soda pop and crackers equal super healthy.  None the less, carbonated beverages and salt - preferably with sea salt are in fact good for some conditions.  Pepsi and white flour processed salt crackers isn't the breakfast of champions however...

 

coolGjyla Toplica I am pro-cannabis for pregnant women, because I was one of those woman... I had Hyperemesis which was severe nausea and vomiting. My body was treating my son like a parasitic disease instead of a baby... I lost 60 pounds by the 5th month of my pregnant...

 

Editor`s note:  No one should have to go through the miracle of pregnancy in absolute hell.  This is where some intelligence is required, to assess, at what point do we use a medication, and is medical cannabis the best choice, and if so, what is the best type.  These are the core questions.


 

coolCindy McCluskey: Yes I used it with all four pregnancies I ended up in the hospital with everyone on IVs because of dehydration I would've been there more if it hadn't been for marijuana

 

coolDeborah Bacon Cannabis because of the many ways it can help you and you don't just need to smoke to experience its benefits! The company making Zofran has changed its formulation. Cannabis is safer because it's still natural and it's formulation has NOT been changed by humans.

 

coolHeather Bassett Yes helps for first through second month. Doesn't need to be consumed every second. Baby turns out fine and lives a great life.... Just make sure the herbs are tested and clean of little bugs etc. Sorry for those who think it's horrible...

 

coolAngela Robinson I have literally talked to 100s of moms, who consumed with their children while pregnant and 100s of adults whose moms consumed with them. Not one single negative story and even the suggestion of it being beneficial to development. Mainstream medicine will never admit this. People are sheep when they believe main stream anything nowadays.

 

coolJackie Scales Cannabis, it worked for me!!

 

coolTroy Robertson They say take Zofran of course..its FDA approved..fuc***k

 

coolDebra Barritt I have 3 very intelligent children, never hurt them a bit, and made pregnancy a lot more bearable

coolJoanne Colli Sorry but this is ridiculous. I have nothing against pot smokers, but when you're pregnant, there are many other ways to help ease hyperemesis. I had it severely, and dealt with it as part of being pregnant. It's not fair to the unborn child. Suck it up, don't damage your child's brain before they even get a chance to fully develop.

 

Editor's Note: We agree with Joanne and also disagree with her.  It may be that it is best to grin and bear it in many cases of morning sickness, but she's simply not aware that some morning sickness cases are life threatening, where the mother does not stop vomiting up every meal throughout the entire pregnancy.  These so called super cases require intervention.



coolDeleting Deleting But then again its ok for women to take pills to take away nausea that causes heart defects. Either way.. As much as it sucks. Women need to just deal with it naturally

coolDiana Madrigal Of course marijuana, it's dangerous to the pharmaceutical companies

coolDaniela Francesca Chudy I am not against weed. It does wonders for ppl that are sick in pain. But smoking it or eating it during pregnancy is ridiculous. Your baby is developing and you're taking a drug that is impairing his/her development. I just could never do it.

 

Editor's note: Raw cannabis does not have any "drug" properties at all as the THC is inactive, and hemp also does not contain "drug:" THC whatsoever.  Edibles however have activated THC however, and higher concentrations and chronic use are of concern in pregnancy.

 

coolLeya-Ravine Ezell Smoking cannabis no. Infusing it in teas, cookies, candies and pure oil yes. A woman should not smoke anything while pregnant. But I'm all for infusing it in other ways.

coolLinda Carnahan be careful, if the hospital does a meconium drug screen and it comes back positive, child protective services has to be called, now probably nothing will happen, but who wants them in your lives?


 

Editor's note:  If you choose to use a drug for morning sickness, obviously the one you want to choose the least toxic one - for you and your baby.  You should also have a relationship with a health care professional that knows about both medical cannabis and the pharmaceutical alternatives, should intervention be required.

 

coolNoemi De Gomez Haha! Wow this is so ridiculous!! The more we have, the less we wanna suffer. Women are able to bare the pain of childbirth and yet they come up with epidural to ease the pain and now this!!!!

 

Editor's note:  A little morning sickness - for a couple of weeks is normal and taking medications of any kind has no upside, except momentary relief.



coolRose Vasquez That is crazy, there are over 200 unidentified chemicals in cannabis. What you put in your body is your business, but we are talking about babies who can't protect themselves!

 

Editor's note:  There are 200 identified compounds, most in very trace amounts in cannabis and the LD50, the toxicity data is known for all of them.   In combination, the total toxicity is near zero, i.e. it would take a bale of cannabis to kill you, and that's only if it hit you on the head.


coolMichelle Lynn I mean seriously? Like this is news to women that they can't smoke during pregnancy? Wait I can't drink COFFEE during my pregnancy, but I can smoke a BLUNT? That seems logical...you don't want the morning sickness don't get pregnant...is it really worth giving your child issues? It's a teratogen that affects the growth of your baby just like cigarettes, alcohol,etc

 

Editor's note:  The issue here is extreme morning sickness, if you medicate, is cannabis a viable and safe option?  It is obvious for the human race to survive thousands of generations, one cup of coffee or one drink is not going to upset the applecart, so to speak.  Getting drunk, drinking coffee to excess, smoking pot several times per day, these are the focal risk factors obviously.  However, pardon the pun, the obvious facts are, too often, like throwing the baby out with the bathwater.

 

"The highest form of ignorance is when you reject something you know absolutely nothing about." - Shelbee Rydawne

 

coolCeline N Cipres Really just another reason for someone to not be healthy while pregnant, there are other ways to cope with sickness, it's natural!! While pregnant it should be a time you want to stop all the bad stuff to make sure your baby and yourself is healthy!

coolNancy M Del Rio, Ridiculous !! Women need to deal with the morning sickness, it's part of being pregnant!!  And yes I did!! I worked until I could ...dealt with my morning sickness ... worked hard without calling out.

coolJoe Garcia My girl better not smoke cigarettes or weed period while having our 1st 2nd 3rd 4th 5th child otherwise I'll ....OMG


coolSheila Pelayo Actually, there are more complications due to cigarette smoke then there are for weed. My 9 month baby girl is EXCELLING past older babies! She is perfectly healthy and smarter then I could ever think. Her dr is impressed every visit. To each their own.

coolBrenda Bernal I thought about it when i was 9 months pregnant to ease the excruciating sciatic pain, but even the thought of it made me feel so guilty, i just dealt with it !

coolShawnee Lee Bolling Marijuana is safe during pregnancy. Do your research. It doesn't hurt the baby's development either. My daughter has been early on all her milestones and has impressive motor skills. If you're throwing out judgement, know that you're making yourself look uneducated.

coolEdward Schanze My daughter was born with a cleft palate do to this crap.

 

Editor: Was Edward`s sperm defective, like his brain???


coolKimberly Acosta Trinh Anthony Trinh I would never do that but man did I need something while pregnant with Anthony I wonder if that's why he throws up so easily too.

coolBrian Alexander-Pleitez Gonzalez Go back to the Indians before the 13 colonies or maybe the Aztec Mayans, Inca etc etc weed has been a remedy since before one can imagine ignorant people gonna put an Angry face, but you be surprised what the plant does for one body.

coolMandy Vargas Everyone should chill out and test 100 of these women's babies when they are born, if they are all good y'all could go back living in the 60s and under a rock.

coolJasmin Reyes De La Vara  ****** learn to deal with it!!! You guys decided to open your legs and get pregnant then deal with it naturally, if that baby could talk it would definitely tell you to stop!!!


 

"Everybody talks tough until they get hit in the head." - Every boxer knows.


 

coolLiz Lopez Suck it up butter cups! Stay as healthy as possible for that innocent baby growing inside you!!! 9 months is really not that long.

 

Editor:  Karma insists that Liz Lopez be struck with 8 months of vomiting 12 or more times per day, losing 30 to 40 pounds, and her baby is stillborn.   Nasty comment, but people have no clue.  On the other hand, of course ladies can suck up normal morning sickness for a few weeks or so.....



coolTrianna Morales you know they tried to test this theory that cannabis damages the fetus of an unborn child ...while they were having the trial...they also used women who weren't just smoking pot, but also doing other substances such as smoking cigarettes or drinking ...so they never had a clean group who just smoked cannabis and therefore made it seem that cannabis was bad when it's not

coolJimmy N' Stefanie Silva Nancy Ceballos to me this is selfish. I had a tough pregnancy and smoking weed was never on my mind. Sucks for babies, dude.

coolErin Simone Sampson Weed does NOT damage your brain....it in fact slows down your blood flow to your brain so that it can gain more brain cells....dealing with hyperemesis is not always just a option...if you don't eat the baby doesn't eat...and I believe weed is safer th...

coolBrittany Siufanua SO no harmful effects come from smoking weed during pregnancy. i told my doctor it was the only thing that worked. I lost about 26 lbs because i couldn't keep anything down....my doctor said well there isn't anything bad about smoking weed for that, but he is old school so he says just tough it out...so either way i think people should know it won't affect the baby....

coolNoelle Royea I find it funny how uneducated the public is. Do you realize doctors OK you to take drugs during pregnancy that are for cancer patients in zofran, they give you the okay for as much liver damaging Tylenol as you want, vicodin,soma etc. So you're tellin...

coolAmber Lee It does A LOTTT More than just help with morning sickness. You can go natural, suffer from emotional swings due to hormones, stress out, raise your heart rate, have no appetite, constantly nauseous, remain uncomfortable, over think, under indulge....

coolAnita Glover I'm all for smoking, but if you're pregnant you're gonna need to not smoke. Your baby will not be able to function properly. It'll take them longer to understand and comprehend

coolWendy Kal That's not good! I wouldn't even drink regular tea during pregnancy... that will have side effects for the baby.


coolIdalmis Herrera This isn't true. I known many people that have smoked cannabis and they have very heathy kids. The Doctor recommended one joint only within a week. Equals two or three puff a day. It is helps with women that are addicted to Cigarettes. Cigarettes are extremely poisoning to the Fetus but pot isn't.



Committee Opinion No. 722: Marijuana Use During Pregnancy and Lactation.

Cannabis sativa-cannabis is the illegal drug most commonly used during pregnancy. The self-reported prevalence of cannabis use during pregnancy ranges from two percent to five percent in most studies. A growing number of states are legalizing cannabis for medicinal or recreational purposes, and its use by pregnant women could increase even further as a result. Because of concerns regarding impaired neurodevelopment, as well as maternal and fetal exposure to the adverse effects of inhaling marijuana, women who are pregnant or are thinking about it should be encouraged to discontinue cannabis use.

Obstetrician-gynecologists should be discouraged from prescribing or suggesting the use of cannabis for medicinal purposes during preconception, pregnancy, and lactation. Pregnant women or women contemplating pregnancy should be encouraged to discontinue use of cannabis for medicinal purposes in favor of an alternative therapy for which there are better pregnancy-specific safety data. There are insufficient data to evaluate the effects of cannabis use on babies during lactation and breastfeeding, and in the lack of such data, cannabis use is discouraged.

Our take: No evidence is put forward in this study the shows that cannabis is a dangerous, though the advice might be sensible.  The core issue is not addressed; is marijuana a relatively safe medicine for severe cases of morning sickness where the mother's health is in mortal danger?

 

420EvaluationsOnline Notes:  We provide 100% online medical marijuana recommendations, Cannabis Medical ID, and grower's permits.   The process takes only a few minutes to complete and patients are not asked for payment, until they have been approved.  Documents are used only in the State of California and at some locations in Nevada ... at dispensaries, delivery services, cooperatives, cannabis and compassion clubs.

 

ORTHODOX DRUGS FOR MORNING SICKNESS

Doxylamine Succinate Tablet COMMON BRAND NAME-S: Unisom Sleep Aid

Common doxylamine side effects:
 

  • confusion, hallucinations
  • severe dizziness or drowsiness
  • little or no urinating
  • blurred vision
  • dry mouth, nose, or throat
  • constipation
  • mild dizziness or drowsiness

According to Wiki doxylamine is much more toxic to babies.   Not recommended for common morning sickness.
 

Committee Opinion Summary NO. 722: Marijuana Use During Pregnancy and Lactation.

Cannabis sativa-marijuana is the illegal drug most commonly used during pregnancy. The self-reported prevalence of cannabis use during pregnancy ranges from two percent to five percent in most studies. A growing number of states are legalizing cannabis for medicinal or recreational purposes, and its use by pregnant women could increase even further as a result. Because of concerns regarding impaired neurodevelopment, as well as maternal and fetal exposure to the adverse effects of smoking, women who are pregnant or contemplating pregnancy should be encouraged to discontinue cannabis use.

Obstetrician-gynecologists should be discouraged from prescribing or suggesting the use of cannabis for medicinal purposes during preconception, pregnancy, and lactation. Pregnant women or women contemplating pregnancy should be encouraged to discontinue use of cannabis for medicinal purposes in favor of an alternative therapy for which there are better pregnancy-specific safety data. There are insufficient data to evaluate the effects of cannabis use on babies during lactation and breastfeeding, and in the lack of such data, cannabis use is discouraged.

 

Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

The broad-based legalization of cannabis use has created a strong need to understand its impact on human health and behavior. The risks that may be associated with marijuana use, particularly for sensitive subgroups such as pregnant women, are difficult to define because of a paucity of dose-response data and the recent increase in marijuana potency.

Although there is a large body of evidence detailing the mode of action of d9THC in adults, little work has focused on understanding how marijuana use during pregnancy may impact the development of the fetal nervous system and whether additional plant-derived cannabinoids might participate.

This manuscript presents an overview of the historical and contemporary literature focused on the mode of action of d9THC in the developing brain, comparative pharmacokinetics in both pregnant and nonpregnant model systems and neurodevelopmental outcomes in exposed offspring. Despite the growing public health significance, pharmacokinetic studies of d9THC have focused on nonpregnant adult subjects and there are few published reports on disposition parameters during pregnancy.

Data from preclinical species show that d9THC readily crosses the placenta although fetal exposures appear lower than maternal exposures. The neurodevelopmental data in humans and animals suggest that prenatal exposure to d9THC may lead to subtle, persistent changes in targeted aspects of higher-level cognition and psychological well-being. There is an urgent need for well-controlled studies in humans and preclinical models on d9THC as a developmental neurotoxicant. Until more information is available, pregnant women should not assume that using marijuana during pregnancy is safe.

 

Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis.

We conducted meta-analyses of relationships between highly prevalent substance use during pregnancy and offspring conduct disorder problems. In total, 36 studies were included. Odds ratios -ORs were 2.06 -1.67-2.54, 25 studies for maternal smoking, 2.11 -1.42-3.15, 9 studies for alcohol use, and 1.29 -0.93-1.81, 3 studies for marijuana use, while a single study of caffeine use reported no effects.

Our meta-analyses support an association between smoking and alcohol use during pregnancy, and offspring conduct problems, yet do not resolve causality issues given potential confounding by genetic factors, gene-environment interactions, and comorbidity such as with attention deficit hyperactivity disorders. Future studies should use genetically sensitive designs to investigate the role of pregnancy, substance use in offspring conduct problems and may consider more broadly defined behavioral problems.

 

For Debate: Does Cannabis Use by the Pregnant Mother Affect the Fetus and Newborn?

Cannabis, commonly called cannabis, is often used during pregnancy, likely due to the perception that it is a "safe" drug. Changes in legislation in many countries have led to the increased availability of this drug and to its increasing use during pregnancy, often with other concomitant exposures such as alcohol, tobacco, and other drugs. We review the public domain medical literature relating to the effects of cannabis on the fetus and newborn.

Possible effects of in utero exposure to cannabis focus on fetal growth, increase in the rates of stillbirth and preterm delivery, congenital malformations, and neurodevelopmental effects on the child. Published studies for all these outcomes are inconsistent. Fetal weight growth may be somewhat decreased, but the magnitude of this decrease is no greater than 100 g. There is insufficient evidence to conclude on any effect on the stillbirth rate.

Although there are some reports of a slight increase in the rate of prematurity, most reports do not support this effect. Marijuana does not appear to be a major teratogen; however, a small increased risk for some congenital birth defects may be associated with early pregnancy use.

Neurodevelopmental effects have been associated with cannabis use, but it is difficult to control for the effect of confounders. Despite the lack of conclusive evidence, it is important to remember that cannabis has not been shown to be a harmless drug during pregnancy and may affect the long-term neurodevelopment of the newborn infant.

Our take: Marijuana use, in populations that are poor, with poor diets and with a high incidence of drug abuse and domestic violence show no greater than 1/5 of a pound decrease in baby weight compared to the national average.  This is a very positive finding given this this outlier population.

 

NEGATIVE STUDY (POPULATION OF SUBSTANCE ABUSERS USED)

A case of cannabinoid hyperemesis syndrome with Helicobacter pylori and preeclampsia during pregnancy.

BACKGROUND: The condition termed cannabinoid hyperemesis syndrome -CHS was characterized a decade ago by Allen et al. and includes cyclic episodes of nausea and vomiting and the learned behavior of hot bathing in individuals with chronic marijuana abuse. During pregnancy, the differential diagnosis of this syndrome is challenging, since it can be masked by typical symptoms of early pregnancy or by hyperemesis gravidarum, a complication of early pregnancy associated with excessive nausea and vomiting.
 

CASE DESCRIPTION: A case of a 21-year-old primigravida patient diagnosed with hyperemesis gravidarum at 6 weeks of gestation and with preeclampsia at 35 weeks. At 30 weeks of gestation, a drug screen was performed that was positive for marijuana; therefore, a diagnosis of CHS was made. After labor induction, the patient delivered an infant who developed normally and had a negative drug test of the umbilical cord blood.

Esophagogastroduodenoscopy was performed 9 days post delivery, with biopsies taken of the duodenal, gastric, and esophageal tissues. Moderate chronic gastritis with lymphoid aggregates and slight acute inflammation were noticed, whereas no malignancy, dysplasia, or goblet cell metaplasia was detected. A number of Helicobacter-like organisms were identified by H. pylori immunostaining.
 

CONCLUSION: Presented here is the first case reporting an association of chronic marijuana use with H. pylori colonization and preeclampsia in pregnancy, which brings to light the possible involvement of a cannabinoid-related pathway in the link between pregnancy-specific complications and bacterial colonization.

Editor's note:  This study is an embarrassment. A statistic of 1 one patient - rules out any serious consideration, what so ever, of this result.

 

Clinical Inquiry: What effects--if any--does cannabis use during pregnancy have on the fetus or child?

The effects are unclear. Marijuana use during pregnancy is associated with clinically unimportant lower birth weights -growth differences of approximately 100 g, but no differences in preterm births or congenital anomalies.

Scarcity of Data - Placenta as alternative specimen to detect in utero marijuana exposure: A systematic review of the literature.

The use of marijuana during pregnancy and lactation is widely recognized as a health concern. The placenta is one of the several biological matrices that can be used to detect in utero drug exposure with the distinct advantage of easy and noninvasive collection. We conducted a PubMed search to investigate the pharmacokinetics of cannabinoids, the active constituent of marijuana, in the placenta.

The majority of the selected twelve papers was before 1990 and concerned animals at term gestation with great variability of experimental conditions. Only three were about human population and two of them reported equivocal findings on pre- term placenta. Our systematic review confirms that placental marijuana pharmacokinetics has been scarcely investigated and that further research is needed to determine advantages and disadvantages for monitoring maternal d9THC use or the degree of in utero exposure.

 

Marijuana Ingredients Reach Mother's Milk - Pharmacologic Implications of Marijuana Use During Pregnancy.

Marijuana is the most commonly used recreational drug in the United States, including and among women of childbearing age and women who are pregnant. Changing legal statutes that allow for the use of medical cannabis and the decriminalization of cannabis for personal use reflect more permissive societal views on the use of this drug. Active compounds in cannabis cross the placenta rapidly and are excreted in breast milk.

Results of studies of the effects of cannabis on a developing fetus and neonate are conflicting, but researchers have identified chronic cannabis exposure as a risk factor for preterm birth and small-for-gestational-age babies. This article summarizes the pharmacology of cannabis and discusses implications for nurses who work with women of childbearing age.

 

Editor's notes:  Cannabinoids make it into the mother's milk, as do the body's own endocannabinoids, which are necessary for proper function of almost all body systems.  This points to the possible efficacy of cannabis in pregnancy, but also points to potential dangers.

 

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Veritas’ mission is to develop effective cannabis therapies that combat chronic pain, acute pain, emesis (nausea and vomiting) along with other conditions and to provide conclusive evidence as to the efficacy of these treatments to doctors and patients alike. Veritas Pharma has quickly progressed from screening numerous cannabis strains to identifying several potential strains. These are truly exciting times for our Company. We invite you to receive a personalized update on the Company’s plans and developments and address any questions you may have. CONTACT [email protected]   +1-416-918-6785.

 

Labels: morning sickness hyperemesis gravidarum pregnancy marijuana and pregnancy

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