I switched my practice to nutritional support, hormone balancing of the neurotransmitter support.  Instead of taking Prozac, how about some 5-HTP?  You know, using things that are naturopathic and alternative solutions.  We are so familiar with and work with pharmaceuticals, but that was not at all part of our conventional medical practice, certainly not the way I was trained.  


Dr. Mercola:  It's beyond irrational and the only justification is that the DEA is influenced and controlled, or is a puppet of the pharmaceutical industry, because they're the only one that benefits from this position, because there’s no justification in a irrational scientific based system, for this decision so…

Dr. Margaret Gedde: Yeah, It’s ironic that cannabis was put on schedule one, with the statement that not enough was known about it, so therefore they were going to put it on schedule one…

Dr. Mercola:  Yeah, which may have been reasonable…

Dr. Margaret Gedde: Until sometime later, which that was never applied to any other substance…

Dr. Mercola::  So when was that?

Dr. Margaret Gedde:… It was put on for the absence of information…

Dr. Mercola:  How long ago…

Dr. Margaret Gedde: …Things (drugs) were put on because it was known.

Dr. Mercola:  How long ago was it classified schedule one, and I’m not even sure when the classification system was developed.

Dr. Margaret Gedde::  It was back in the seventies, it was right with the passage of the Drug  Enforcement Act.  I think it was 1970 and there are those who looking back at the history, and what President Nixon was doing at the time, they  can rightfully conclude, there were some quotes that came out the news.  I think last year from him, from Nixon back at that time, that a the whole point of restricting marijuana so heavily, was to get the hippies, I mean there’s a whole social battle going on and they wanted something to be able to arrest people, put them in jail, take people out of society and make them non-functional.  Marijuana was targeted, you know we’re getting into all the politics and the social aspects.  

Editor: Marijuana: then is a tool of a fake government that is run from the shadows by the big multinationals.



Dr. Mercola: Sure, well it is an important part of the situation, the politics.

Dr. Margaret Gedde: When you go again, how decisions were made?  it's marijuana that has been targeted. Like you said in the introduction, Cannabis has just been vilified all along, and for what reasons? Maybe it does too much right and it does have the cycle activity, so people can kinda change how they think, and question things, but when we look at cannabis overall, marijuana and hemp combined, and talk about cannabis all the different cannabinoids in there.  

We know that it’s excellent medicine, we know that it’s popular recreationally, which of course competes with the alcohol industry,  and other things.  Hemp provides excellent biofuel, it actually competes with the petroleum industry.  Hemp provides excellent fiber, so clothing... it competes with lumber, which is one of the reasons apparently why hemp was restricted earlier in the twentieth century to help the paper mills.  We hear these different stories,  cannabis is a medicine, a recreational substance, a food, fuel and fiber.  So what else can do all things? Hemp is an excellent food, hemp oil has essential fatty acids of high quality.  The oil  high quality protein, you can actually live on hemp seeds.

Dr. Mercola: Well, first I’d like you to go into more detail as some of the benefits of cannabis, but before you do, I just like to reinforce the fact that you mentioned when it was initially vilified, in the seventies by Nixon, and the DEA's classification of it as a schedule one controlled substance.  That was it was sort of a way of getting back at hippies, but just to clarify, you weren’t one of those hippies, because you were a conventional medical physician until 2004, which is literally only a dozen years ago..  

Dr. Margaret Gedde: Yes…

Dr. Mercola: So it’s not like you were prejudiced, or have been smoking weed for fifty years or forty years. Whatever.   

Cannabis is the best medicine

Dr. Margaret Gedde: Me? No, No... (right, she never smoked)

Dr. Mercola: So you came to it, so I think before you go into the benefits and the uses of CBD, and some of the other components,  maybe it might be wise to share your journey, as to why you shifted.  You could obviously shift your position in your viewpoint on this, because obviously,  you were traditionally based in conventional medicine, and you shifted.  

So why did you shift?   

Dorian Yates - DMT - Cannabis - London Real

Dorian Yates on DMT and Cannabis 

Dr. Margaret Gedde: Yep!  You know I was trained in the idea; that we’re going to study molecular biology, we’re going to understand the details of how cells work, and for every disease, we’re going to design a drug.  For every disease, we will have a new drug with pharmaceutical development.  But then I did I think it was because of working inside the pharmaceutical industry, and starting to see how decisions are made, and of course, we know that companies that are publicly traded for profit.

Corporations are supposed to make money, that’s sort of their legal right.  But  that means when they're choosing  things (drugs) to develop, it’s not necessarily the things that people need, it's the things that will make money.  So you know, it’s a sort of an obvious thing, but it’s also a cynical thing, and it took me a little while to realize.

Wait! This isn’t actually, this drug we're developing, it isn’t really the thing that the people need.  We could do another one (that helps more), but that won’t make money.   So I realized, that there are non-pharmaceutical, non-patentable, more holistic and supportive options.  Then

It was an epiphany,  it was kind of a turning point in my career, it was kind of a big thing to leave the pharmaceutical industry and open my first alternative practice.

I had so much to learn.  That was in 2004, but that was a long before, I realized that marijuana was medicine.  I didn’t realize that at all, and it wasn’t until 2009, when the medical marijuana program did start becoming big in Colorado, with the administration that was  new at that time, because people were very optimistic, and figured that it would be possible to expand.  Then someone said, you know, you’re a doctor, why don’t you see some patients to give cannabis recommendations, and only then I started to hear people say this really works.  Marijuana does work medically, for example, people with chronic nausea with inflammation.    

This really helps you, oh! Yeah! It's  life changing, you know, day and night, so I learned not from the books, not from articles, because we didn’t have those in medicinal school.       

We didn’t learn about the endocannabinoid system, which I’m sure we'll touch on today, it's so important.  It’s not part of required medical education, but it is a very, very important system, that runs all of our bodies. So when I started hearing about the results patients were getting and then I realized that the reason, why this could do so many different things in the body, without being toxic, is because it is acting through this natural endocannabinoid system in our bodies.  That’s why I said wow!

This is huge, there’s nothing like this in medicine, there’s nothing I can prescribe that comes close to what this can do for people.  So it was in early 2010 that I decided to focus my practice full-time on medical cannabis.  So yeah, following what really helps people, what people really need is what brought me to focus on this.


Dr, Mercola backs medical marijuana.

Dr. Mercola: Okay, Great!  Well, I really appreciate you sharing your backstory, because it helps get though, there are view is a better understanding of how you reach your conclusions, so I’m wondering now, if you can really go into the endocannabinoid system, and differentiate, you know, does that include the CBDs and the THCs?  Is all of them?  And Endo means to work from within our own body system?. This is not some external component, what these plants (cannabis) are doing, is triggering something has been in us since the beginning (of the human race).

Dr. Margaret Gedde: Since the beginning, yes, the cannabinoid system is in all mammals as well.  It’s an ancient system, so yes, in the plant's cannabis it makes these cannabinoids, we can refer to those as phyto cannabinoids, plants cannabinoids, they do in encompass THC, CBD.   I believe there are about 60 different cannabinoids that are counted in the cannabis plant, and we work with several of them directly in the medical program.  The plants makes the phyto cannabinoids, in our bodies, we make our own human cannabinoids.  There are two major ones that have been identified, and that have been studied now, well since the early 90s.  

This endocannabinoids system was first described in a science journal in 1992, which first describe the system and talked about how key it was for the human body.  It turns that the role of this endocannabinoid system, where we release our own human cannabinoids, and they interact with receptors through all tissues in the body.  The role is to bring balance, homeostasis to each of the other systems, so the endocannabinoid system has a finger in every pie, and it and it has a key regulatory role.  There are endocannabinoid receptors in the nervous system, and it’s a very interesting part of this system, that the cannabinoids are made locally on demand, so that would be a reason why it’s been difficult to study.  


The Endocannabinoid System

For example, what that means in the nervous system, we can think about two nerve cells,  the sending one and the receiving one, and the endocannabinoid system works with that sending and receiving. The receiving nerve cell becomes too excited, like in a seizure, you’ll have uncontrolled electrical activity in the neurons.  So there’s an over excitement state, an over stimulated state.  There’s a receptor that can detect the state in the nerve cell,  the endocannabinoid system detects that the cells is over stimulated, and then on-demand makes these oily substances, the human cannabinoids.  

And it’s an anandamide and 2-arachidonoylglycerol, the system's lipids, they're oily substances.  So again, it's more difficult to study it, and makes sense, that it wasn’t this system, it wasn’t described as soon as others, and how it affects how the cannabis works in the body, because it is oily, so it distributes in the tissues in a different way, so it has a big impact on how we can use it, so on-demand, the cannabinoids made in the cell - that’s being over excited and then the stimulation, where the human cannabinoid goes to signalling the cell and it dials it down, so it says okay, this cells getting too much stimulation, so we’re going to go back on the sending one, and dial it down, so it does this process in every tissue, so as it’s been studied.  For example, cannabis induced homeostasis brings things back into balance, so it can reduce pain, reduce nerve stimulation, reduce seizures of course reduce muscle spasm, lets people relax, lets people eat, lets people sleep, so it is a very key system, and then it totally make sense, why the marijuana can do so many different things.  

This explains why it affects the mind, it will affect the emotions that affect the body, on multiple levels, and that’s that’s the THC.   CBD does as well.  CBD has multiple of targets in the body, the system seems very complex, there are multiple receptors and it’s not known how CBD acts.  It acts in a different way from THC .  There’s much, much to research, but this is a very rich system.  It is very, very involved in our other body systems.  For those who write about this and record on it in the scientific literature, it’s very frequently said, if this were being looked the first time, it would be in all headlines hailed as an incredible boon to mankind, because it can actually work through this natural system, and do so many things without being toxic.  So many pain medications are damaging to the stomach, to the gut.

Cannabis doesn’t hurt the gut, it helps heal the gut, there’s people that are so relieved, they say this isn’t gonna hurt me, it’s actually helped my stomach.  There’s nothing else that does that, in that it won’t hurt the organs, it won’t hurt the liver, won’t hurt the kidneys. You can't stay on  Ibuprofen for months and years people.   But they can't stay on that (pharmaceuticals), the cannabis as we know well, there is no known lethal dose for cannabis, whether THC or CBD.  A person couldn’t die from it, even if they were trying really really hard.  There’s nothing you can say about it,  except that it offers so much people on a medical level.

The many benefits of medical marijuana

Dr. Mercola: What about the adverse side effects, potential adverse side effects?  Obviously fatalities aren’t one of them.  People don’t die from cannabis, unlike, what it is commonly used for would be opiate addictions, which people are dying from; during this interview, there’s two or three people who probably died, people who died while they’re watching this.   There will be two or three people who died while you listen to the whole interview from opiate addiction, so there is no toxicity of marijuana,  but fatal toxicity with opiates.  There some people are concerned about schizophrenia long term schizophrenia or psychotic episodes as a results of THC,  or I mean, I know anxiety is an issue, and concern, but that’s an acute episode that’s not going to  kill someone, and it resolves once the effects of the drug wear off,  so perhaps you can address that.

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Dr. Margaret Gedde: The effects of THC and CBD are very dose dependant, so this substance or substances, that have what we could call a bell-shaped response curve, where there really is, for most people, what we could call a sweet spot, where you need enough, but not too much.  So for THC, in small appropriate doses.  A person might be taking it to relax,  it settles the stomach, it helps people feel better.  If it’s too much, as you just mentioned, THC can definitely cause anxiety.   THC can cause nausea, it make people feel terrible, feel like they don’t even know where they are.  They’re spinning, so that’s the difference in the dose, so the right dose will be very, very soothing and very helpful, very beneficial.  


Another interesting and helpful property of the cannabis is  that it’s self-limiting, in in comparison to opiates, you know when there there is too much cannabis, but you don't know with opiates,  there’s no too overly high-dose,  in terms of the sensations of the patient, they just in a very  relax state, in place of white light.   What people say with the opiates, there’s no point at which a person says, "Oh! this is terrible,  I don’t want to do this".  There's always the need to do more opiates (toward overdose), but with the cannabis, it does have that self-limiting effect.  


So we absolutely work closely with patients on the dosing.  You want to start with a lower dose and because it is an oily medication, and it does interact with the body in a different way.  The cannabis can build-up in the fatty tissues overtime, so we get this build-up effect that’s very beneficial.  So I explained to people that it’s just the flip side of the fact, that many people know,  if someone needs to take a THC drug test, they’ve been using marijuana, it can take three to four weeks literally to fully clear out that THC from the person’s body.  Whereas alcohol and other drugs are water-soluble, they clear very quickly.

So the cannabis clears slowly, it also builds up slowly.  You have about a three-week time to steady-state, so we explain this to patients to say, you can start a certain dose, as you take that same dose day after day, it’s gonna build up for three or four weeks, so you can wait and see where the build-up effect gets you, before you go to the next level.   So that they’re not using more than they need, not having extra side effects, the side effects are generally the psychoactive ones,  with the THC again, too much could just make a person feel very altered and unlike themselves.  

We always caution people on that because I don’t like patients to have a bad experience, so that they shy away from some of the more effective methods, which would include the swallow down cannabis edibles, that has the longest lasting effect, but if the dose is too high, it is wrong, it can be very unpleasant experience, so that’s the biggest thing we warn about..  

We warn about too high doses of THC,  that would cause impairment, and you know, cause a very uncomfortable unhappy experience.  The biggest thing is for people to know their own responses, and know well.  I guess that’s the extent, to know if they’re capable of driving with what levels are in their system, and I’ll refer to the pharmaceutical package insert, the prescribing information for the synthetic form of THC, dronabinol marinol.  In that package, which is scheduled three, ironically, it says, don’t operate heavy machinery or drive a car until you are familiar with the effects on you.  So that seems like you know a good approach.  

As far as concerns about psychosis or schizophrenia, you can definitely induce a psychotic state with THC, where the person is disoriented.  They don’t know even who they are.  You can do that now, that will be reversible, that is not a permanent state, once it does clear out the body and it wears off.  There is research in literature that’s been building for a while, that suggests that young people, who already have a tendency to schizophrenia, maybe they will be diagnosed with schizophrenia, where they will have an episode, those people seem to come to diagnosis sooner if they’ve been using marijuana, but it’s not clear at all that the THC causes schizophrenia, or if cannabis brought it out.  

Even so, this is still under debate.  It is such an interesting thing, we talked about adverse effects even though we don’t have much, at all, research into the benefits of cannabis, and we have very few controlled human studies.  We (Federal Gov) had 40 plus years, put out of a lot of money,  put researchers into the task of finding out everything bad about marijuana.  There’s been a lot of research, where they were trying to find out every every adverse thing, and so we know that it can be impairing people,  we have to be cautious about operating machinery, there’s the suggestion that it could bring out schizophrenia sooner, but this is debated, as far as we know.  What is that correlation actually, are people who tend to become schizophrenic, are they more likely to use marijuana, so it’s it’s actually not a clear correlation?  

Probably the biggest concern is simply that, in the developing brain in young people, all the way up to the age of 25,  it’s certain the cannabinoids act on the brain, it seems that THC can change brain development in such a way, that it would be later when a person, in their twenties would show a lower level of executive function, being able to plan and organize, and a little bit lower IQ, so this is the most recent place we’ve got to.  

There are kind of battling studies going back and forth, or one come out and say clearly you know young people should not use this, and  look at this correlation with bad outcomes, and someone  else will say no, look you didn’t control 4xyz.  If we control this, we see that actually, the reduced outcome correlates with socio-economic status, so really despite all of these decades of research into bad things, the things that seem to be real, that we need to be concerned about, even aren’t very clear.  We need to know more about them, so it really does come down to that.

We don’t have to caution people about hurting their stomach, watching for bleeding, or watching their liver tests.  It’s there as far as the cautions, for or against adverse events, it really does relate to those helping them to find the right doses, that give them the benefits they need, without adverse effects of too much, and then just recognizing that psychoactive effect of the THC, especially for new users.  But when we get the dose right, it could be very smooth and and very productive.     

Dr. Mercola: Alright, well thank you for that comprehensive response.  I really appreciate it. It is reassuring to know, like most of herbal or plant preparations, that there is this intrinsic self-limiting feedback, that allows you or  actually prevents you from taking too high of a dose over time, which is the exact polar opposite of what you see in the drug model, especially with opiates, you know you die of respiratory suppression or depression…  click here to read more MORE...

420EVALUATIONSONLINE:  Despite the Federal government's ongoing war on marijuana, the State of California and Nevada allows citizens to buy CBD, THC and cannabis based medicines provided that they have a licensed recommendation for marijuana issued by a medical doctor.  The recommendation process can be completed online here.  The process is fast, same day and affordable.  Just select the correct answer to some multiple choice questions and click finish, and a licensed physician will evaluate your conditions and symptoms.  Patients only pay if they are approved.  420RecommendationsOnline recommendations and Cannabis ID  are accepted by dispensaries, cooperatives, compassion clubs, and other vendors of cannabis based medicines.



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