Can Cannabinoids improve Thyroid function?


Cannabis and Thyroid Disease    


"A 2002 animal study found evidence that CB1 receptors regulate the release of thyroid hormones T3 and T4, and that the administration of cannabinoids influenced the hormonal activity and suggest a role of cannabinoids in the regulation of thyroid hormonal activity."


In 2016, our Thyroid - Cannabinoids article went viral, out of the blue. So, this year we've taken a second look at the topic, knowing there is a large audience waiting.  Since, in 2017-8 several medical papers verified previous findings and suggest that CBD especially can definitely help modulate and normalize thyroid and adrenal function.   


The Takeaway - Cannabinoid receptors are found in abundance in both the adrenal and thyroid glands.  The effect of cannabis in modulating glandular function is profound and immediate, as seen in effects of: couch lock, anxiety, relaxation, motivation, invigoration and creativity.  While precise clinical data toward the efficacy of the individual cannabinoids, THC, CBD and others remains on the frontier of medicine, the obvious action of the cannabinoids to moderate bodily function systems points to probably very therapeutic benefits.


Where can you smoke marijuana legally in California - and avoid being busted like the Champ?


In lieu of clinical of the required medical studies, we do have an abundance of evidence which is presented below.  Cannabis cannabinoids are anti-cancer and anti-inflammatory, which implies efficacy in Thyroid cancer and inflammatory issues that dramatically affect thyroid activity.


Cannabinoids produced in the body - or from plant sources, particularly cannabis, affect the adrenal and thyroid cells CB1 receptors to produce more or less hormones that cause anxiety, depression, lethargy or hyperactivity.  People with these conditions know if cannabis works or not, simply by the effect, the ability to relax, unwind, sleep or focus. CBD especially has an indirect effect on thyroid conditions because it can induce deeper sleep, which in turn, affects the thyroid to repair and work less to shore up energy deficiencies.  



How Cannabinoids Affect Glandular Function


As stated previously, the body's own endocannabinoid system is responsible for regulating balancing thyroid function, among so many other bodily systems.  The endocannabinoid system is activated by cannabinoid receptors located on cell membranes of many kinds of cells. The affinity for the different cannabinoids causes an antagonist or agonist cascade of biochemical reactions, that effective dial up and dial down a function.  There are two clearly identified and well studies cannabinoid receptors, named CB1 and CB2.


An outrageously, but somewhat effective description of how cannabis works in glandular conditions, is that the THC "dials up" the CB1 receptor, while CBD, the second most common cannabinoid in many strains, acts to "dial down" activity of the CB2 receptor ,which incidentally is not found in the thyroid and adrenals in quantity.  


However, CBD is a moderator (dial down) of THC with the observed tendency to optimize its function.  The ability of CBD to dial down the CB2 receptor is especially evident in the case of rampant inflammation, where reduction autoimmune symptoms is demonstrated in many medical research papers and clinical trials.  ** See Google PubMed for details.


CB1 receptor is most predominant in the thyroid and adrenal glands, as well as nerve and brain tissues.  To resolve how cannabinoids work in the glandular system, we must first understand the biochemistry, which is initiated at the receptors on glandular cells.  Certain endocannabinoids and the phytocannabinoid (plant derived) THC effectively dials up the release or synthesis of biochemicals that:


  • Lowers Anxiety and Stress

  • Alleviates Post Traumatic Stress Disorder

  • Ameliorates Depression

  • Helps Induce Sleep

  • Increases Myelin and BDNF

  • Lowers Intestinal Inflammation

  • and CB2 Suppress Mast Cells

  • Lowers Blood Pressure

Sleep Apnea & Insomnia - Medical Marijuana Research Papers Worldwide - 2000- 2017  





"Endogenous cannabinoids are important signaling molecules in neuroendocrine control of homeostatic and reproductive functions including stress response and energy metabolism. The hypothalamic paraventricular and supraoptic nuclei have been shown to release endocannabinoids, which act as retrograde messengers to modulate the synaptic release of glutamate during stress response."


The endocannabinoid system at the level of the adrenal, can directly influence activity - in the adrenocortical steroidogenesis.  The data indicates the expression of CB1 in human adrenal cortex and adrenocortical cells; CB2 was not expressed. Furthermore, anandamide inhibited basal release and stimulated release of adrenocortical steroids (corticosterone and aldosterone); this effect was reversed by CB1 antagonist.." - 10.1055/s-0029-1241860. Epub 2009 Oct 27


Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. The research here focuses on three of these compounds, d9-THC the main psychoactive component, cannabidiol or CBD, the second most common non-psychoactive component and d9-THCV which has a few less carbons on its "tail" which deliver a distinctly and sometimes opposing effect compared to the most common for of THC, the d9 isomer.  In most strains available in America today, CBD and THCV are found in trace amounts, however, selective breeding and the introduction of strains from round the world has yielded varieties with therapeutic quantities of THC-V and CBD."


An individual's genetics, the cellular and intercellular biochemistry, and especially expression of the proteins coded in the receptors and molecular cascade of events that follow.   The cannabinoids THC, CBD, CBN, and many others interact with cannabinoid CB1 and CB2 receptors in different ways, and the reaction depends on genetics, personal biochemistry, and dosage.  In small quantities, the receptor can be triggered to dial up, but in massive amounts the reaction can be opposite, and vice versa.


Got it? Is this explanation as clear as mud?  Fortunately, the real situation while complex, we are able to get down to the bottom of many aspects of cannabinoid therapeutics. .  


THC dials up CB1 receptor


d9-THC, the main constituent of marijuana, is a CB1 and CB2 receptor partial agonist, the expression level and signalling efficiency of cannabinoid receptors and by ongoing endogenous cannabinoid release.


CBD dials down CB2 receptor, modulated CB1 receptor which means that couch lock was lessened, relaxation enhanced, inflammation trended down.

Thousands upon thousands of people believe that CBD helps them sleep very well to wake up fully energised and refreshed. Here ar



CBD displayed potency as an antagonist of CB1/CB2 receptor agonists in CB1- and CB2-expressing cells or tissue, explaining ability to inhibit evoked immune cell activity..


THCV dials down the CB1 receptor, but still dials up psychoactive activity


d9-THCV is a CB2 receptor partial agonist the lab. In contrast, it antagonizes cannabinoid receptor agonists in CB1-expressing tissues. Interestingly, d9-THCV also interacts with CB1 receptors in vivo (in animals), behaving either as a CB1 antagonist or, at higher doses, as a CB1 receptor agonist in lower doses. " -


Cannabinoids synthesized naturally in the human body and those absorbed from plants like CBD interact with these cannabinoid receptors assist in maintenance of homeostasis.

Scientists found that cannabinoid receptors located on cells on the thyroid gland. Cannabinoid receptors have also been identified within the hypothalamic nucleus tissue of the brain that sends signals to the thyroid to regulate activities.

Cannabinoid receptors on the thyroid and brain send signals to the thyroid suggest that CBD and other cannabinoids influence glandular health and performance.  A 2009 study found cannabinoid receptor type 1 (CB1) – directly influences the activity of the neurons that control the thyroid.

The presence of both symmetric and asymmetric type CB1 synapses on thyroid complex neurons suggests that endocannabinoids may influence both excitation and relaxation.


Medical Marijuana is a very old medicinal herb used for thousands of years to treat insomnia, mental issues, pain, inflammation, intestinal conditions and cramping.  The active ingredients of Marijuana, called Cannabinoids, have been shown to have anti-bacterial, anti-cancer, anti-inflammatory and anxiety reducing properties.

There are many issues, the condition could be cancerous, there may be a deficiency in iodine, infection or fluid build up, a benign tumor, infection or other disorder.  The amazing thing about the Cannabinoids of cannabis is that they have been clinically shown to help every one of the listed thyroid conditions.

With that said, consensus research findings at this point indicate that Medical Marijuana is an adjunct therapy but the evidence is mounting that many forms of thyroid issues cold be treated with cannabis as the primary.




The thyroid is a gland located in the middle of your neck.  The Thyroid produces hormones to regulate metabolic rate, underactive, you'll feel tired, overactive, you'll be hyper them burnt out.

Thyroid issues range from somewhat benign goiter to life threatening cancer.  Most thyroid problems involve an abnormal production of thyroid hormones, which can be successfully managed, however, side effects can be significant as medications are somewhat toxic.

Levothyroxine is used to treat an underactive thyroid as it replaces or provides more thyroid hormone, which is normally produced by a healthy thyroid gland.  Side effects include irregular heartbeat;fever, flashes, sweats; insomnia; changes in menstrual periods, vomiting, diarrhea, appetite changes, weight and hair loss.

Thyroid Issues Hyperthyroidism: an overproduction of thyroid hormones

Graves' disease features irritability, muscle weakness, sleeping issues, fast heartbeat, poor tolerance of heat, diarrhea, and weight loss.

Marijuana is recommended by California Medical Doctors to treat all of these conditions listed above.

Toxic adenomas: Nodules in the thyroid gland secrete thyroid hormones, upsetting the chemical balance.

Marijuana Cannabinoids has been shown to induce suicide in rogue cell (tumors).

Subacute thyroiditis: Inflamed thyroid that causes leakage of excess hormones. Cannabinoids reduce inflammation.  The cannabinoid, CBG kills Methicillin-resistant Staphylococcus aureus (MRSA), a cause of inflammation.

Pituitary gland malfunctions with cancerous growths in the thyroid gland.

Medical Marijuana in high doses has anti-cancer activity.  gram level THC per day.


Hypothyroidism or underproduction of thyroid hormones equals lower energy levels, can induce coma and even result in death.

Hashimoto's thyroiditis autoimmune disorder, the body attacks thyroid tissue and cells eventually die when thyroid hormone dwindles.

Medical Cannabis components, especially CBD and THC modulate downward inflammation throughout the entire body.

Exposure to excessive amounts of iodide from drugs, heart drug amiodarone, dyes given for  X-rays causes thyroid malfunction. Lithium is implicated in hypothyroidism; can bring on a myxedema coma, potentially fatal condition that requires immediate hormone replacement therapy.

Pituitary disorders can cause an interruption in the secretion of thyroid stimulating hormone. Pituitary disorders are often caused by tumors and medical Marijuana has shown anti-tumor properties.

Cancer:  5% of thyroid nodules result in Cancer. The US Cancer Institute found that Marijuana can KILL Cancer.


Nodules and Swelling are benign 95% of the time, you want to take preventative measures to reduce the size and growth of nodules.Multiple thyroid nodules are common and rarely cancerous.  Multinodular situations don't usually require surgery unless you have problems swallowing or breathing.

Diffuse goitre is usually caused by autoimmune thyroid conditions, Hashimoto’s thyroiditis and Graves’ disease.

Retrosternal goitre   Multinodular thyroid can grow from behind the breastbone.impinging and constricting the windpipe (trachea) and the large veins in the neck and esophagus.  If the growth and/or inflammation cannot be reduced, surgery is the final option.

Colloid and Hyperplastic nodules. These are benign lumps don't usually require surgery.

Thyroid adenoma  This benign lump can resemble cancer in scans and biopsy and needs confirmation by microscopic examination.

Thyroid cyst. swelling with fluid that removed with a needle or surgery, but healthy living and other therapies may cause cysts to shrink to non-threatening size.

Thyroid cancer is rare, in this procedure, most or all of the thyroid and the nodules are removed.  with thyroid replacement therapy.


Marijuana is used to treat some of the symptoms of Graves’ disease not the disease itself. Symptoms that can be treated with medical marijuana are; reduce eye pressure, reduce anxiety, relieve insomnia, reduce irritability, encourage appetite/weight gain, relieve restlessness / nervousness, slow or relax heart rate. It certainly won't hurt her and may improve her quality of life while she waits to begin her treatment.

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