BOTOX & CANNABIS CREAM
Skin creams containing 5% each of CBD and THC
This article is exclusive to MMJDOCTORONLINE.
We now know that the phytocannabinoids, the main medicinal ingredients of cannabis have deep, subtle but profound impact on skin tissue. Thanks to the innovative cultivation techniques of growers round the world, we have access to strains with extremely concentrated amounts of Cannabinoids, like psychoactive THC, other types of THC and the very medicinal CBD.
THC & CBD - Properties Verified in the Clinic
Enhance Collagen formation
Enhance Bone Growth
Reduce Scar tissue
Suppression of Inflammation that leads to facial structure degeneration
Normalize pigmentation formation
Stimulate smooth muscle and deep tissue
Concentrated Cannabinoid Creams used in conjunction with other therapies like: Plastic Surgery, Botox, Platelet Rich Plasma, Laser, Microdermabrasion, CBD, THC help heal and improve the cellular foundation of the skin, facial bone and muscle tissues.
WHY CANNABINOIDS ARE ONLY NOW ENTERING THE COSMETIC MARKETPLACE
While the clinical research data presented here is fresh off the press, various folk topical cannabis remedies for wounds and skin conditions were, in fact, used for thousands of years, In America and much of the western world, however, for the past eighty years, this eons old medical knowledge was wiped from the record, the death of cannabis based medicines started through sinister prohibition in 1932.
This diabolical process - that would become the War on Drugs - caught the country napping, the science and the history of hemp and cannabis was literally erased from the mainstream public record and consciousness, for cannabis was removed from the medical texts and pharmacy shelves.
"The good news is that many effective techniques in the cosmetic industry work well."
In fact, over the past century, nearly every naturally occurring medicinal molecule was edited out of the medical texts or replaced with patentable synthetic derivatives, in the name of bigger profit. Thus, from top to bottom, the medical industry was transformed into a money-meat machine, with blood money going to doctors, educators and above all else, a small group of billion dollar pharmaceutical companies.
"Suppression of the body's errant inflammatory response has proven to be an effective therapy of Collagen-created arthritis and these findings led to the successful use in clinical studies with RA patients. It was found that Cannabidiol-CBD has a useful therapeutic action on established CIA, and we explore its mode of action."
On the surface, it appears that capitalism is to blame for this inhumane process of turning medicine into a ruthlessly profitable business. However, it is readily apparent that anti-capitalistic forces were at work to achieve this apocalyptic version of reality. A cabal of old big money gradually infiltrated every level of government, to create a playing field where only they would succeed.
Through social programs and regulations, they milk the public for untold billions per year, worldwide, their chunk of world health care is several trillion $, all told. This is the way across the planet, socialism - which inevitably leads to a defunct private sector - is milked by anti-human corporate interests, interests in not necessarily maximizing profits, but simply controlling everything, and eliminating all competition.
This bastardization of medical science plays contrary to the common fundamental organic chemistry principles, where biological systems are adapted to use or eliminate molecules that exist in their native environments, whereas synthetic molecules are not usually exact copies of the original organic forms and as a result, they are not typically absorbed, until zed or eliminated properly, resulting in severe toxic side effects, dependency and downgrade the metabolism.
CANNABINOIDS REGULATE BONE, DEEP MUSCLE AND SKIN FORMATION
Cannabinoids can normalize aberrant production of collagen, the proteins that intertwine to form skin tissue cells. As we age, the quality of our collagen degrades which is reflected in thinner, inelastic and weak skin tissue, all of which data in an older appearance. Other proteins degrade, that are involved in facial bone replacement and muscle tissue growth.
All of these proteins have been shown to be controlled in part by the endocannabinoid system. Endocannabinoids are produced within the body naturally and as we age, or in the case of imbalance, our endocannabinoids that that are in short supply can cause defective action in the nervous, motor, brain, autoimmune, cardiac, respiratory, digestive and other systems.
In the case of appearance, where the skin tissue, facial muscles and facial bone structure integrity are paramount to a youthful appearance.
Phytocannabinoids, new therapeutic agents in skin tissue disorders. - Hill AJ1, Williams CM, Whalley BJ, Stephens GJ
CANNABIS HAS MANY MEDICINAL THINGS IN IT
The Cannabis plant can contain over 100 cannabinoid compounds, it's been used for thousands of years for both recreational and medicinal purposes. In the past two decades, characterisation of the body's endogenous cannabinoid technique has highlighted activation of central CB receptors by the main phytocannabinoid, d9-THC as the primary mediator of psychoactive and medicinal effects.
MEDICINAL MOLECULES IN CANNABIS THAT DON'T GET YOU HIGH
While d9-THC is the most widely studied phytocannabinoid, it is also the predominant psychotropic component of marijuana, a property that can limit its therapeutic use as an isolated agent. In this regard, research focus has recently widened to include other phytocannabinoids including cannabidiol-CBD, cannabigerol-CBG , 9 tetrahydrocannabivarin, d9THC, and cannabidivarin some of which show potential as therapeutic agents in preclinical models of CNS disease.
Moreover, it is becoming evident that these non-d9-THC cannabis cannabinoids act on a wide range of pharmacological targets, not solely limited to CB receptors. Disorders that might be targeted include epilepsy, neurodegenerative diseases, affective disorders and the central modulation of feeding behaviour. Here, we review cannabis cannabinoid impact in preclinical models of CNS conditions and, where available, clinical medical study data that back therapeutic impact. Such advances may soon deliver the first non-d9-THC phytocannabinoid-based medicines.
INFLAMMATION CAUSES MULTIPLE FACIAL ISSUES
Acne is a common skin tissue condition, characterized by higher sebum production and inflammation of the sebaceous (secrete oil and wax) glands. We have previously shown that a non-psychotropic cannabis cannabinoid cannabidiol-CBD exerted complex anti-acne impact by restoring 'pro-acne agents'-created exaggerated sebaceous fatty production, reducing the generation and alleviating inflammation.
Therefore, in this scientific study, we aimed to explore the putative anti-acne impact of further non-psychotropic cannabis cannabinoids.
cannabichromene - CBC
cannabidivarin - CBDV
cannabigerol - CBG
cannabidivarin - CBGV
d9 -tetrahydrocannabivarin - THCV
CBD MEDICINAL PROPERTIES RELATED TO FACIAL ISSUES
Clinical improvement using cannabinoids correlated with enhanced protection of the joints and tendons against damage.
Lymph node drainage cells from CBD-treated rodents showed a diminished generation of harmful protein (IFN-γ) production, and also a decreased release of tumor causing cells in the joints and fluid about the bones.
Effects of CBD in the lab included a dose-dependent suppression of white blood cell generation which accounts for harmful errant autoimmune responses that complicate many facial issues - allergies, puffy eyes, sinus blockage that leads to a distorted facial appearance, lessening of blood flow, wrinkles, etc.
CBD was capable of blocking a chemical that causes tumors; lipopolysaccharide which was associated with the increase of tumors in rodents.
CBD has combined immunosuppressive and anti-inflammatory actions which affect not only the body, but related greatly to good health and improved facial appearance.
CBD , has potent anti-arthritic effect in protein collagen-created arthritis, which assists in the rebuilding of facial tissue, leading to a more youthful appearance.
See Further Reading Section for Details on the Experimental Data.
CBD AND THE SKIN
Cannabidiol-CBD is one of the main components of marijuana sativa, marijuana . Marijuana contains approximately eighty constituents classified as cannabinoids. CBD is not psychoactive, unlike the other major component of marijuana - known as d9-tetrahydrocannabinol-d9THC. A vast array of medical documents finds that cannabinoids can dial down the body's immune system's rogue activity, both in the clinic and the lab.
"A list of clinical and laboratory findings includes the suppression and proliferative of the various immune cells, the suppression of macrophage or white blood cells function, antigen presentation, and inhibition of nitrous oxide production by white blood cells."
The probable anti-inflammatory features of CBD, together with the lack of psychoactive effect and low toxicity, prompted researchers to test the potential of CBD as a therapeutic agent in protein collagen-created arthritis, a disorder that also leads to disfiguration in facial tissue and appearance.
"Facial Erosion Explained. Collagen-created arthritis is elicited by immunizing rodents with type II protein collagen. The immune response involves both humoral and cellular mechanisms. Collagen-created arthritis is characterized by quick onset of joint inflammation, resulting in destruction of joint tissues and cartilage/facial bone erosions."
In facial cosmetic applications, Botox is considered very safe and effective for lessening of facial wrinkles, especially in the upper third of the face. Injection of Botox into the facial muscles under facial wrinkles causes relaxation of those facial muscles, resulting in the smoothing of the overlying skin tissue.
"There are millions of Botox procedures performed each year in the United States and the product would not still be on the market if it weren't safe. The main serious risks of Botox come from very high doses used for treating specific medical conditions such as muscle spasticity. The amount of Botox commonly used to treat wrinkles is very safe. Of course, no procedure or treatment is without any risk, but the overall safety profile of Botox is excellent. There is an extensive track record of many millions of patients treated over more than ten years." - Mitesh Kapadia, MD, PhD
Smoothing of wrinkles is usually visible three days after therapy and is maximally visible two weeks following injection. The treated facial muscles gradually regain healthy function, and generally return to their former appearance three to four months after therapy. Facial Muscles can be treated repeatedly to maintain the smoothed appearance.
While Botox is generally considered safe in a clinical setting, there can be serious side impact from its use. Most commonly, Botox can be injected into the wrong muscle group or spread from the injection site, causing paralysis of unintended facial muscles.
"There are two types of Botox procedures and people often confuse them - Botox Cosmetic and Botox Therapeutic. These are two different things, which the Botox website does lay out and explain. For Botox Cosmetic, rarely are more than 100 units at a time used (this would be for the underarms for hyperhidrosis; in the face it's more an average of 50 units). These are considered elective procedures for cosmetic improvements." - F. Victor Rueckl, MD
Side impact from facial cosmetic use generally results from unintended paralysis of facial muscles. These include partial facial paralysis, muscle weakness, and trouble swallowing. Side impact can also include headaches, flu-like symptoms, and allergic reactions.
Facial cosmetic therapies only last a number of months, paralysis side-impact can have the same durations. protein collagen-created arthritis. In some cases, these impacts are reported to subside in the weeks after therapy. Bruising at the site of injection is not a side effect of Botox, but rather from the needle itself, cases to about a week. When injecting the masseter muscle of the jaw, loss of healthy muscle function can result in a loss of power to chew solid foods.
Side impact in facial cosmetic includes trouble swallowing, muscle weakness, allergic reactions, and flu-like syndromes.
The FDA warned that Botox products could spread from the injection site when higher doses were used, generally in non-cosmetic (therapeutic) use.
Ultherapy is a new FDA-approved procedure that lifts, tighten and tone skin. The therapy is indicated for lifting the eyebrow and lifting lax submental beneath the chin and neck. Follow up therapies are required every 12 months to maintain data
"The procedure uses Ultrasound. The best use for Ultherapy is as a non surgical brow lift to open up the eyes."
The Laser therapy procedure is non invasive, but the procedure is painful, so sometimes a local anesthetic is used. Ultherapy is conducted on the brow, neck, and under the chin but it can be performed anywhere. There’s no downtime, foreign substances, or radical change; just a tune-up on the inside for a noticeably natural effect on the outside.
Ultherapy works differently to lasers in that it target thes outer layers on the skin. Ultherapy bypasses the surface of the skin and delivers ultrasound vibrational energy to the deepest layers of the skin - which causes damage to the protein collagen layers of the skin tissue and this in turn builds new protein collagen.
Ultherapy penetrates the dermis, sending ultrasound frequency that promotes protein collagen production. Ultherapy Is causes pockets of damage by heating the deep layers of the skin tissue, which stimulates protein collagen production.
Ultherapy side impact includes mild to moderate redness and swelling, discomfort, bruising, nerve damage and scarring with a 2-3 day of downtime. Use sunblock anytime you go into the sun after the procedure.
Before therapy, the physician marks the area to be treated with a pen. A full face therapy takes an hour. With topical anesthetic, there is mild discomfort and without it can be quite painful, particularly towards the end of the therapy.
Notable plastic cosmetic surgeons, facial cosmetic surgeons and dermatologists offer Ultherapy, include: Lancer Dermatology Clinic, Rodeo Drive Dermatology Clinic and Aesthetics, Leaf MD, Wave Plastic Surgery Center, The Center for Advanced Facial Plastic Surgery, Rebecca Fitzgerald Dermatology Clinic, Mudgil Dermatology Clinic, Grace Dermatology Clinic, New York Dermatology Clinic Group, Union Square Dermatology Clinic Group, Boston Dermatology Clinic and Laser Center, Boston facial cosmetic Surgery Center, Fox and Schingo Plastic Surgery and Dermatology Clinic Associates of Huntington.
SKIN SPOT REMOVAL
Lasers tend to be the safest and commonly effective therapy for removing brown sun damage spots from the skin tissue. Lasers and Intense Pulsed Light devices purge brown spots and patches from the skin tissue by selectively targeting the melanin and melanocyte, leaving the other cells in the skin tissue untouched.
Lasers give off a single very specific wavelength of light-targeted to purge brown spots; these devices break up the excess melanin which causes discoloration.
Laser therapy procedure requires no anesthesia. One or two sessions are required.
INTENSE PULSED LIGHT
The Intense Pulsed Light Device was created to treat combinations of skin tissue issues. Intense Pulsed Light therapies decrease the irregular brownish and reddish locations of aging and sun damage. In addition, Intense Pulsed Light brightens the skin.
An Intense Pulsed Light machine delivers a broad range of colors of light. Filters are then used to selectively deliver light at various wavelengths. Different wavelengths of light penetrate and treat different layers and depths of the skin. Intense Pulsed Light therapies can effectively decrease diffuse brown pigmentation and blotchy redness on the face, neck, chest, arms, and legs.
Treatments take 15 to 30 minutes. There are no needles; no anesthesia with no downtime.
Brown spots that were treated darker, then fade and flake off.
Microdermabrasion is a simple, painless, non-invasive facial cosmetic procedure to purge the layer of dead and damaged skin tissue cells The procedure is in two parts, one, an exfoliating material like crystals or diamond flakes and a machine based suction to gently lift up the skin tissue during exfoliation.
Typical microdermabrasion sessions can last anywhere from 5 to 60 minutes. Irritating products like glycolic acids, Alpha Hydroxy Acids, Retinol products or fragranced creams and lotions are typically avoided right after the procedure.
A crystal microdermabrasion technique includes a pump, a connecting tube, a hand piece, and a vacuum. The pump creates a high-pressure stream of inert crystals of aluminum oxide, magnesium oxide, sodium chloride, or sodium bicarbonate that abrades the skin tissue, the vacuum removes the crystals and exfoliated skin cells.
Alternatively, the inert crystals can be replaced by a roughened surface of the tip in the diamond microdermabrasion system.
Unlike the older crystal microdermabrasion system, the diamond microdermabrasion does not produce particles from crystals that may be inhaled into patients’ nose or blown into the eyes. Hence, diamond microdermabrasion is regarded as having higher safety for use on places around the eyes and lips. Generally, the slower the movement of the microdermabrasion handpiece against the skin and the greater the numbers of passes over the skin, the deeper the skin tissue therapy.
One of the best and safest methods of microdermabrasion involves the use of corundum or aluminum oxide crystals suspended in an antioxidant cream. This version of microdermabrasion is generally the common cost efficient as it involves the use of a small handheld skincare tool instead of expensive equipment used by a salon. This technique of microdermabrasion rose to popularity in the early 2000s and is widely available today.
Often called “microderm” for short, microdermabrasion is a procedure to help exfoliate or temporarily purgea few of the upper layers of the skin tissue called the stratum corneum. Much like brushing one's teeth, microdermabrasion helps to gently purge skin “plaque” and skin debris.
Since human skin tissue typically regenerates at approximately thirty-day intervals, skin tissue improvement with microdermabrasion is temporary and needs to be repeated at average intervals of two to four weeks for continued improvement. Many therapies together with sunscreen, sun avoidance, and other skin care creams deliver better data.
Dermabrasion is generally used to refer to a true surgical procedure that aggressively abrades away the upper to mid layers of the skin. The term microdermabrasion generally refers to a non-surgical procedure that abrades less deeply than dermabrasion. Although the mechanism of the two procedures is similar, the difference in the depth of the abrasion data in different recovery times.
Dermabrasion recovery time may take as much as several weeks to several months, whereas microdermabrasion recovery time may be as little as one to two days. After microdermabrasion, skin tissue will be much more sensitive to sun exposure. It is best to keep out of the sun and wear sunscreen at all times after the procedure.
Microdermabrasion may be performed to help diminish the appearance of superficial hyperpigmentation, and photo-damage, and also a diminish fine lines, wrinkles, acne, and shallow acne scars and marks. A further gains of microdermabrasion is enhanced skin tissue penetration by other skin cream formulations and serums. Removing dead and damaged skin stratum corneum of the epidermis will aid in the penetration of skin care products and medications by up to 10-50 percent. The controlled skin tissue exfoliation afforded by microdermabrasion will allow makeup and self-tanning products to go on much more smoothly.
Microdermabrasion therapy carries minimal to very few possible side impact or issues. However, some patients may experience temporary, mild dryness, sun sensitivity, and rarely temporary bruising or scratches in the area of skin tissue treated.
PLATELET RICH PLASMA
Platelet-rich plasma is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to purge red blood cells. It has a greater concentration of growth factors than whole blood, and has been used to encourage a brisk healing response across several specialties, in particular plastic cosmetic surgery, dentistry, orthopedics and dermatology.
As a concentrated source of blood plasma and autologous conditioned plasma, Platelet Rich Plasma contains several different growth factors and other cytokines that can stimulate healing of soft tissue and joints and tendons. There are many indications as in sports medicine and orthopedics acute muscle strains, tendinopathy and muscle-facial injuries and osteoarthritis, or dermatology androgenic alopecia, wound healing, and skin tissue rejuvenation. For preparation of Platelet Rich Plasma, various protocols are used, with an underlying principle of concentrating platelets to about five times physiological levels, then injecting this concentrate in the tissue where healing is desired.
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In humans, Platelet Rich Plasma has been investigated and used as a clinical tool for several types of medical therapies, including ongoing tendonitis, osteoarthritis, for facial bone repair and regeneration, in oral surgery, and in plastic cosmetic surgery, for example using a platelet-rich fibrin matrix method.
"The American Journal of Sports Medicine published a paper which concluded that "application of three consecutive Platelet Rich Plasma injections greatly enhanced symptoms and function in athletes with ongoing patellar tendinopathy and allowed quick recovery and return to sport."
A meta-test reviewed five hundred studies on Platelet Rich Plasma for osteoarthritic knee and indicated that only nine were worth considering and concluded that with respect to short term outcomes, Platelet Rich Plasma was not more efficacious than placebo in total W.O.M.AC. score, but was more efficacious than hyaluronic acid HA on that measure; it was no different than placebo or Hyaluronic Acid with regard to adverse events.
Data of basic scientific and preclinical studies has not yet been confirmed in large-scale random controlled studies. A systematic review of the scientific literature indicated there were few random controlled studies that adequately evaluated the safety and efficacy of Platelet Rich Plasma therapies and concluded that Platelet Rich Plasma was "a promising, but not a proven, therapy option for joint, tendon, ligament, and muscle injuries".
A random control medical study concluded that Platelet Rich Plasma was greatly better for osteoarthritic knee than hyaluronic acid.
A *Cochrane test for Plasma Rich Therapy use to treat musculoskeletal injuries indicated very weak, very low quality data for a decrease in pain in the short term, up to three months and no difference in function in the short to long term.
A systematic review and meta-test of random controlled clinical studies for Platelet Rich Plasma use to augment facial bone graft indicated only one scientific study reporting a significant difference in facial bone augmentation, while four studies indicated no significant difference.
Proponents of Platelet Rich Plasma therapy have argued that negative clinical data are correlated with bad-quality Platelet Rich Plasma produced by suboptimal single spin devices. The fact that common gathering devices capture a percentage of a given thrombocyte count might bias data, because of inter-individual variability in the platelet concentration of human plasma and more would not necessarily be better. The variability in platelet concentrating techniques may alter platelet degranulation characteristics that might affect clinical outcomes.
In the field of aesthetics and plastic cosmetic surgery, the clinical application is particularly wide and is under the name of Regenerative Plastic Surgery. Platelet Rich Plasma correlated with adipose tissue, is given for breast reconstruction, facial soft tissue defects, lower extremity ulcers and scars and marks. Promising data were obtained in the therapy of androgenetic alopecia, as emerging from scientific studies published since 2013.
Among these, the most significant by impact factor is the random scientific-clinical study of the clinical-instrumental evaluation of the effect of Regenerative Plastic Surgery in androgenetic alopecia published in 2015 by Pietro Gentile et al. and a multidisciplinary team at the University of Rome Tor Vergata The Effect of Platelet Rich Plasma in Hair Regrowth: A random Placebo-Controlled Trial.
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Dermabrasion is a type of surgical skin tissue planning, typically performed in a professional medical setting by a dermatologist or plastic cosmetic surgeon trained specifically in this procedure. Dermabrasion has been practiced for many years (before the advent of lasers) and involves the controlled deeper abrasion (wearing away) of the upper to mid layers of the skin tissue with any variety of strong abrasive devices including a wire brush, diamond wheel or fraise, sterilized sandpaper, salt crystals, or other mechanical means.
Ultherapy is a new FDA-approved procedure that claims to lift, tighten and tone skin tissue. The treatment is indicated for lifting the eyebrow and lifting lax submental (beneath the chin) and neck tissue. The cost of Ultherapy is about $4000 and most people need three treatments. However, follow up treatments are recommended every twelve months to maintain results.
The therapeutic implications of cannabidiol CBD , the main non psychoactive component of marijuana, was explored in murine protein collagen,created arthritis, protein collagen-created arthritis or protein collagen-created arthritis was elicited by immunizing rodents with type II protein collagen.
The CII used was either bovine or murine, resulting in classical acute protein collagen-created arthritis or in ongoing relapsing protein collagen-related arthritis, respectively. CBD was conducted after onset of clinical symptoms, and in both models of arthritis the therapy effectively blocked progression of arthritis. CBD was equally effective when dosed i.p. or orally. The dose dependency showed a bell-shaped curve, with an optimal effect at 5 milligram/kilogram per day or 25 milligram/kilogram per day orally.
CBC and THCV lowered it, and CBDV had only slight impact, whereas CBG and CBGV increased it. Importantly, CBC, CBDV and THCV greatly reduced arachidonic acid AA created 'acnelike' lipogenesis. Moreover, THCV lowered generation, and all cannabis cannabinoids exerted remarkable anti inflammatory actions. Our data suggest that CBG and CBGV may have potential in the therapy of dry skin syndrome, whereas CBC, CBDV and especially THCV show hope to become very efficient, new anti acne agents. Moreover, based on their remarkable anti inflammatory actions, cannabis cannabinoids might be efficient, yet very safe new tools in the management of cutaneous inflammations.