CANNABIS TRENDING TO #1 - INFLAMMATION & AUTOIMMUNE DISEASE
" According to the National Institute of Pain, Cannabis has 20 x the antiinflammitory power of Asprin."
A doctor hesitated in prescribing CBD to a patient with an autoimmune disorder, that same patient was taking a gigantic cocktail of pharmaceuticals, including pregnenolone. The Doc said, CBD works, but we don't know enough about it. After picking our jaw up off the floor, to tame the ignorance, we set about writing of this article, which references about one hundred research reports - relating to solely to cannabis and inflammation - from renowned institutes from across the planet.
CANNABINOIDS - THE BEST SOLUTION TO INFLAMMATION - RIGHT NOW?
Cannabinoids modulate the two types of receptors found in immune system cells that control inflammation
Cannabinoids can increase programmed cell death in immune T cells
Studies show that THC, THCV, CBD attenuate (dial down) both receptors that control immune response
Cannabinoids have a very lower level of toxicity
THC and CBD are better tolerated than steroids and other pharmaceuticals, by a very wide margin
A google, medical literature search reveals no cases of malpractice involving THC, CBD or other cannabinoids
Several cannabinoids show anti-bacterial, antiviral, and antimicrobial properties
Cannabinoids interacts can contradict or complement other medicines
WILL CANNABINOIDS BECOME THE NUMBER ONE ANTI-INFLAMMATORY DRUG?
Cannabinoids are defined medically as a substance that attenuates or moderates the body's cannabinoid receptors. There are two main cannabinoid receptors that have been studied thus far. The CB1 receptor is greatly affected by psychoactive d9THC, the main ingredient of most types of American marijuana.
In fact, the discovery of THC itself led to the discovery of the cellular receptor system, hence the name. The CB1 receptor is predominant in the brain and nervous system while the CB2 receptor is found predominantly in the cells that comprise the immune system. The cannabinoid CBD interacts powerfully with the CB2 receptor with only a minor effect on the CB1 receptor. Later it was discovered that both CB1 and CB2 receptors have reside in immune cells, which explains why so many cannabinoids affect and modulates the immune response.
"Most research focuses on the generall efficacy of Cannabis, THC and CBD. It is virtually certain that an individualized custom mix of with other cannabinoids and terpenes in varying ratios stands to greatly amplify the therapeutic effect in inflammation and other conditions. This concept is very exciting to both sufferers and researchers of auto-immune diseases alike."
Recently, research studies have demonstrated that suggests THC and other cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that the administration of THC in mice triggered apoptosis - cell death in rogue immune T cells and dendritic cells, which resulted in immunosuppression. Interestingly, the same cannabinoids that suppress immune response also exhibit antimicrobial properties simultaneously.
"Cannabinoid receptor trafficking in immune cells is dynamically regulated by a binary biochemical switch and ingredients in marijuana such as THC and CBD." - Biochemical Pharmacology
In addition, cannabinoids were shown to downregulate infection-signaling chemical production; of both cytokine and chemokine. The role of the body's own endocannabinoid system is also involved in immunoregulation and erratic delivery or overproduction of the body's endocannabinoids is thought to lie at the core of errant immune response / disease.
The administration of endocannabinoids of enzymes that break down the endocannabinoids, was shown to lead to immunosuppression and recovery from immune-mediated injury. Manipulation of the endocannabinoid system (agonist and antagonist) using cannabinoids may offer better and safer treatment of inflammatory disorders, due to their especially low toxicity in mammals.
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FURTHER READING - A LOT OF RESEARCH ABOUT WHAT IT DOES
Inflammation & Medical Marijuana An introduction to Cannabis and Inflammation
A wealth of Testimonials and Research Articles that attest to the Benefits of Cannabis in treating Many Kinds of Inflammation.
Cannabinoids as novel anti-inflammatory drugs
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
The endocannabinoid system: an emerging key player in inflammation
Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice
Cannabinoids, endocannabinoids, and related analogs in inflammation
Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the non psychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
Cannabinoids in clinical practice
Pure THC-V inhibits nitrite production in murine peritoneal macrophages
Cannabinoids, inflammation, and fibrosis
Inflammation - Project CBD
Inflammation – Medical Marijuana Research Overview
Why Cannabis Stems Inflammation
Hemp Oil For Inflammation – Studies Show Benefits of Cannabinoids ETH Zurich/Swiss Federal Institute of Technology
Cannabinoids, inflammation, and fibrosis Robert B. Zurier1 and Sumner H. Burstein
Department of Medicine University of Massachusetts Medical School, Worcester, Massachusetts; and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts USA
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