HEALTH A-Z & NEWS

CANNABIGEROL (CBG) - BETTER THAN CBD?

  “Many of us are cannabinoid deficient. A multitude of disorders and their symptoms come come from a deficiency… CBG, the stem molecule which quickly converts to CBD, THC and other cannabinoids.  CBG might turn out to be the most medicinal of the lot ."     CBG Molecule   Cannabigerol (CBG) is a cannabinoid found found in higher concentrations in Hemp as opposed to weed selectively bred for high psychoactive THC content. Most strains of medical and recreational cannabis have minor amounts CBG, somewhere between 0.1 and 1%.  The literature is very sparse and CBG is seldom quantified in industrial Hemp strains but average values appear to range from 0.2 to 2%.   It may be possible to interrupt the enzyme activity which converts CBG into THC especially.  Strains higher in CBG (est. 2-3%) have recently appeared in Europe and these new varieties are expected to appear on the market in the next year or so.   Cannabigerol (CBG) is not psychoactive and is known to block the metabolic action, psychoactive effects of THC. CBG was shown to stimulate neurogenesis (brain cell growth). CBG also is antibacterial, anti-tumor, and helps with insomnia.  Based in the known and implied applications for CBG,   "CBG is the precursor, the stem cell, the mother of THC and CBD.  Until recently, the outstanding medicinal properties of this cannabis constituent were really studied."   All the major cannabinoids - THC, CBD and CBC in marijuana are biosynthesized from cannabigerol (CBG) by the rapid action of enzymes. Early harvesting therefore, doesn’t necessarily lead to especially high amounts of CBG. It may be possible to interrupt the enzymatic action to greatly elevate CBG concentrations.  With that said, it is feasible to extract separate CBG from Hemp in useful quantity.  This is surely that an elite cannabis based medicine supplier will take on some day in the near future.   "Like the other cannabinoids found in cannabis, CBG exhibits is exceptionally non-toxic as compared to most prescribed pharmaceutical preparations.  Observable negative side effects are practically absent in therapeutic doses."   CBG can modulate the fight or flight response. In technical lingo, CNG has a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist. It also binds to the CB2 receptor, but it's action is not well understood as yet (2016).     Potential modulation of the α2-adrenergic receptor by CBG implies the following potential action;   Control fight and flight (stress, anxiety, anger, energy) Suppression of release of norepinephrine (noradrenaline) Stimulates High blood pressure dropping to low. Constriction of certain arteries, heart (coronary artery) Constriction of some vascular smooth muscle, veins Decrease motility of smooth muscle in gastrointestinal tract Inhibition of lipolysis, the breakdown of complex fats (lipids) into fatty acids Facilitates cognition, activity in the prefrontal cortex (PFC; working memory, attention, executive functioning, etc.) Sedative efffects Analgesia effects     CBG has been shown to :   Relieves pain. Slow bacterial growth especially in certain species Reduces seizures and convulsions. Reduces inflammation systemically Induce sleep. Inhibits cancer cell growth Promotes bone growth. Stimulate growth of new brain cells   Conditions under Study:   Glaucoma: Inflammatory Bowel Disease Anti-Inflammatory Disorders Epilepsy Chronic Pain   Evidence that the Plant Cannabinoid cannabigerol blocks pain at the receptor - cellular level.   Evidence that cannabigerol can activate alpha(2)-adrenoceptors, bind to cannabinoid CB(1) and CB(2) receptors and block CB(1) and 5-HT(1A) receptors   Neuroprotective properties of cannabigerol in Huntington's Disease Different plant-derived and synthetic cannabinoids have shown to be neuroprotective in experimental models of Huntington's disease We studied the effects of cannabigerol (CBG), CBG was extremely active as neuroprotectant. improving motor deficits and preserving striatal neurons. CBG reduced proinflammatory markers and improved the levels of antioxidant defenses.  In conclusion, our results open new research avenues for the use of CBG, alone or in combination with other phytocannabinoids or therapies, for the treatment of neurodegenerative diseases such as HD.   Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease.   We investigated the effect of cannabigerol (CBG), a non-psychotropic Cannabis-derived cannabinoid, in a murine model of colitis. In conclusion (it worked), CBG attenuated murine colitis, reduced nitric oxide production in macrophages (effect being modulated by the CB2 receptor) and reduced ROS formation in intestinal epithelial cells. CBG could be considered for clinical experimentation in IBD patients.   Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist   This investigation has provided the first evidence that cannabigerol can activate α2-adrenoceptors, bind to cannabinoid CB1 and CB2 receptors and block CB1 and 5-HT1A receptors. It will now be important to investigate why cannabigerol produced signs of agonism more potently in the [35S]GTPγS binding assay than in the vas deferens and also whether it can inhibit noradrenaline uptake in this isolated tissue and in the brain.   Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats.   Here, we demonstrate for the first time that CBG elicits hyperphagia, by reducing latency to feed and increasing meal frequency, without producing negative neuromotor side effects. Investigation of the therapeutic potential of CBG for conditions such as cachexia and other disorders of eating and body weight regulation is thus warranted.   CBG – The Next Big Cannabinoid Strain   Mikey Kush 25-30% THC 3% Cannabigerol   Micky Kush is a 75% sativa cross between Sweet Irish Kush and Jack The Ripper. ... with earthy, kush flavor with lemon undertones, and deliver energetic, focused effects.... super high THC and CBG especially popular for treating nausea, pain, and depression.....medium height with a moderate to heavy yield, flowers in 7 and 8 weeks.   What is Cannabinoid Profiling?   Cannabinoid profiling informs patients about the concentration of active cannabinoids in their medicine....while THC is the most well-known cannabinoid, it is only responsible for a fraction of cannabis’ medicinal benefits. therefore it is wise to test for CBD, CBDA, CBN, CBG, CBC and THCA....   The Farmer Cannabis Cultivation Network   Bleu Berries (White Label) and Eldorado (Sativa Seedbank) show 1.8% and 1.5% CBG from tests. ..... some Sativa Landraces may have higher CBG but no test results I can find....   THE NEXT GENERATION OF MEDICINAL CANNABIS: HIGH-CBG STRAINS   While it may take some time, have confidence that CBG-only strains will soon be as available as CBD varieties....   CBG – The Next Big Cannabinoid Strain   Mikey Kush strain is a Sativa-dominant strain testing with high levels of CBG and THC levels of 28.6%. CBG marijuana strains are becoming more available in Europe, and will most likely start to be seen on the shelves in North America soon..... 420EvaluationsOnline:  If you find a strain that is high in CBG, you're going to need a medical doctor's recommendation to buy from a dispensary, cannabis clinic, marijuana grow cooperative or delivery service.  We specialize in same day 420 evaluations 100% online... We also provide Cannabis ID Cards and grower's permits valid in the state of California and Nevada.  These online processes follow the guidelines set by the Medical Board of California.

Cannabis and Sleep - The 10 Commandments

Cannabis and Sleep - The 10 Commandments   "I love sleep. My life has a tendency to fall apart when I'm awake, you know?"  Ernest Hemingway   Marijuana is increasingly seen as the safest and most effective sleeping aid.  Even stubborn cases succumb to the right strain of the dreamy herb.  While many people are now aware of this miracle plant's many therapeutic effects, few know how deep the rabbit hole goes.  There is a lot more to it that you think and there are literally hundreds of different cannabis based medicines - that produce different effects, to choose from.   The main Cannabinoids that help people sleep are THC, CBD, CBG and CBN.  THC is psychoactive and accounts for most of the unwanted side effects from marijuana medication.  CBD is currently thought to be the most medicinal of all the cannabinoids and has the least side effects.  CBN is very calming and is present in large quantities of oriental hashish and the traditional version might be the best all round medication out there?  CBG is found in small quantities in certain strains of cannabis.  To get a therapeutic dose, you're going to probably need to contact an elite medical marijuana supplier.     The big 5 cannabinoids (above)   CBD and THC work very differently to induce sleep. Though the molecules are very similar, their action with the two main cannabinoid receptors. CB1 and CB2, is completely different. You might say CBD is like a player that assists on the goal, while THC is the goal scorer...   "Unlike psychoactive THC, which affects cannabinoid receptors directly, CBD has little binding affinity to either the CB1 or CB2 cannabinoid receptors. Instead, CBD indirectly stimulates endogenous cannabinoid signaling by suppressing the enzyme fatty acid amide hydroxylase (FAAH)—the enzyme that breaks down anandamide, the first endocannabinoid discovered in the mammalian brain in 1992." - Project CBD - paraphrase   Each person responds differently, but in any case, you'll be able to tell the difference between THC and CBD no matter who you are.  THC will get you profoundly high, euphoric, dizzy or anxious.  CBD won't do any of these things.  CBD could stop your seizures - immediately, suppress Crohn's or gently calm you down.  Some CBD users say that they are more alert in the morning and more sleepy at bedtime.  It is worth researching which medicine is best for you.   See the further reading section for a comprehensive list of strains of marijuana that patients find are especially good for sleep.   THE TWO POPULAR STRAINS - INDICA & SATIVA Indica cannabis plants are short and stocky with fat leaves, while sativa are taller with leaner branches and leaves.  A sativa can grow to a height of 20 feet, even!   While some Sativa's can call in the sandman, Indica is the strain that most often makes for a better, heavier sleep.  Purple Indica flowers are preferred by veterans.  Though genetics testing has come a long way, many suppliers guess (often correctly) about the ratio of indica to sativa.   Cannabis Aromatherapy with Terpenes Then there is the X factor of the terpenes.  They have profound effects that affect the end result action of both CBD and THC.   Throw in individual metabolic response and this presents an equation to complicated to figure out on paper.  After taking a little direction from theory, trial and error is the only way to go.  In the immediate future a lot more about genetics and the interaction with the different terpenes will surely be known.     The takeaway: Indica with high terpene, CBD and other cannabinoids values might be the best starting point.   Aged Cannabis might be the best formulation.   "CBN is five times more sedating than THC." - Dr. Kymron deCesare of Steep Hill Labs   In the cannabis plant, THC exists in acid form.  This acid, called THCA is not psychoactive.  When you heat THC up, the acid part of the molecule breaks off (decarboxylation) and psychoactive THC is formed.  However, a portion of THCA will convert to Cannabinol Acid or CBNA. Then by heating CBNA it converts into CBN.  CBD is present in large quantity in much of old world traditional hashish.  The effect of this hashish is different from the North American ultra-high THC.  Effects tend to be more balanced, relaxing with lesser side effects, which include paranoia and anxiety.  In the dreamy hashish world, spatial cognition can be compromised however.   "Cannabis that is about 20% THCA, wrapped in a plastic bag sat in a garage for 3 years (in summer heat and dry).  The result, 3-5% production of CBN was produced."   CANNABIS HANGOVER Some cannabis users, particularly those that smoke a lot of high THC weed can feel groggy the morning after.  But this is nothing, whatsoever comparable to a big night out on the town.  You might need a second cup of coffee to get the engines running properly.  If you smoke moldy weed or budd with sprays and pesticides, this can cause a not so subtle hangover.  So if you seem to suffer from any kind of cannabis hangover, try a new strain lower in THC and higher in CBD.  You want to inspect your pot for mold, and buy only lab tested marijuana.     CANNABIS AND MOODS Cannabis high in THC can inhibit REM Sleep and Dreaming which results in less vivid dreams, including nightmares.  Other forms of cannabis, higher in non-THC cannabinoids on the other hand, might enhance dreams.  Studies showed that REM sleep rebound after THC consumption was cut down, leading to more lucid dreams.   TOLERANCE to CANNABIS   Can you and will build up a tolerance to cannabis.  The answer according to many doctors and researchers is YES.  In fact, it is recommended that anyone that uses a cannabis product take a break of maybe one week per month, or 4-5 days on and 2 days off, if cannabis based medicines are to be consumed over the long term.   CANNABIS AND DEEP BREATHING Sleep apnea is a condition where there is an obstruction that causes irregular breathing, which leads, waking up in the night, and leads to a bad sleep in general.  THC was shown to improve 85% of 17 subjects with Sleep apnea, including stabilizing serotonin signaling.   QUITTING CANNABIS AND SLEEP People that quit smoking pot can suffer from a worsening of sleep patterns and a return to pre-existing condition of insomnia.  The suggestion is that if the user in question was taking a strain high in THC, then they might try a strain high in CBD for a while.  Patients can experiment with creams, oral, inhalation and other routes to avoid intoxication and tolerance issues presented by the consumption of large amounts of THC over long periods.   CANNABIS ADDICTION Unless you have a condition like MS, Parkinson's, Epilepsy, Crohn's, recreational use of marijuana in any form is not recommended until a person is fully grown.  Functionally, moderate use won't hurt as you, as cannabis is one of the least addictive and dangerous of substances, lesser so than caffeine, nicotine, opiates, alcohol, cocaine, or even perhaps the most diabolical substance of all, sugar.  Still, some people that love the "holiday" effects of marijuana too much sometimes get into a kind of rut and under achieve.  On the other hand, there a lot of alpha-dogs that love an evening toke of their favorite herb. WHY CANNABIS HAS SO MANY DIFFERENT APPLICATIONS AND EFFECTS   EACH CANNABINOID MOLECULE ACTS UNIQUELY IN THE BODY AT MANY DIFFERENT LEVELS   420 EvaluationsOnline:  To explore the wonderful world of medical cannabis in California and Nevada, you'll need a licensed doctor's recommendation to buy MMJ legally in state, until the year 2018.  Thankfully, the California Medical Board approves of Telehealth, or online medicine.  Using Telehealth, 420 doctor's evaluations can be completed 100% online, at a fraction of the traditional doctor's visit.  We specialize in  same-day  420 evaluations, cannabis ID cards, grower's permits and renewals   Our documents are used to obtain medical marijuana at cannabis clubs, cooperatives, dispensaries, delivery services, and other licensed suppliers of cannabis in California and Nevada.       FURTHER READING THE BEST STRAINS - INSOMNIA AND SLEEP What insomnia and poor sleepers really need is information.  Which strains of medical marijuana work best?  What are the best choices? How do I choose? To best answer these questions we need good data. For a start, we sourced the opinions of the largest weed websites.  Then checked that the strain data included a cannabinoid profile WHAT ARE THE BEST NON-PSYCHOACTIVE - CBD STRAINS OF CANNABIS? At one time, Cannabis strains high in Cannabidiol (CBD) were somewhat of a rarity.  As the testimonials roll in from researchers, patients and MMJ doctors, the efficacy of High-CBD Cannabis has become obvious...   WHY SMOKING MOLDY WEED IS BAD BAD NEWS We raided 30 grow operations and took a  total of 407 fungal spore samples. Two independent types of tests identified elevated fungal spore levels. INSOMNIA & MEDICAL MARIJUANA "Prescription medications for insomnia are intended only for short-term use, but unfortunately, insomnia is not a short-term problem for me. I find that cannabis is effective for me 95% of the time."  - MMJ Patient   Cannabidiol (CBD) Affects the Sleep-wake Cycle Research Article...A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats Medical Marijuana:- Patient Perspective With appropriate use of medical cannabis, many of these patients have been able to reduce or eliminate the use of opiates and other pain pills, Ritalin, tranquilizers, sleeping pills, antidepressants and other psychiatric medicines… Cannabis & Sleep Interestingly, CB receptors do not function in the standard way that we were taught neurons work in our high school and college biology classes. In the standard model, a pre-synaptic cell releases a chemical called a neurotransmitter that crosses the gap...  

CBD OIL KILLS CANCER - FAMILY STORIES

"We started to give my father CBD oil, and the biopsy and graphic showed that 90% of the cancer was dead and the last 10% was completely surrounded by dead cells, which the remaining cancer was likely to die soon as well."   Joe Rogan discusses with MMA fighter Joe Schilling, how marijuana and cannabis oil killed cancer in their family and friends.    This article is paraphrased.  See the further reading section for sources. During the Manhoof training camp, my dad died.   My dad and I had like a weird relationship.  We had a falling out, hadn't spoke in like 10 years.   He came to one of my fights and I found out he had cancer.   My reaction was that I really didn't care.  I hated him, like we had some really bad issues.  My buddy, took me into timeline therapy.  He said, think of a time when you were really proud, think of a time when you were really happy.  And everything seemed intense to revolve around my dad.  It was really weird, after going through it, I lost all resentment toward my father.  It was like this chip on my shoulder my whole life fell off.   For a long time, I used to think about my dad before a fight, you know, to shove it up his ass, to show him I did it my way and won, and fuck him and his loser attitude.  I realized that the anger I was tapping into was holding me back, it was a handicap more than anything.  After the timeline therapy, I went from completely hating him to completely forgiving him. I was able to visit my dad in the hospital. My dad's prognosis was, the was going to die soon from the cancer.   We ended up starting our relationship all over again, there were no apologies needed, just move on.  I had a good relationship in the end but the guy still was an asshole and pigheaded.  He agreed to Cannabis Oil therapy, with CBD but not THC.  There was cancer in his lung, cancer in his brain, cancer in his chest, a massive tumor was on his neck.  We gave CBD oil to him for something like 7 months.  He decided against chemo, he did not want to do it.  We got him vitamins and supplements and he would not take them.  He would not eat properly, only taking in ice cream and cake and shit like that.  We was on a ton of opiate painkillers that were killing him too.   With all that crazy shit, the doctors did their tests and graphs, you know the things that they do, and amazingly, 90% of the cancer was gone.  I have no doubt what so ever that it was the CBD oil that killed the cancer because he was doing absolutely nothing else correctly.  The 10% of the cancer that was still alive was surrounded by dead cells and was going to die out too.   "In the end the fighter's dad died from malnutrition and not cancer, because there wasn't much left.  If you look at the amount of opiates his father consumed, the behavior, the refusal to eat, it's the mirror of a heroin junkies last days, death from complete exhaustion." Joe Rogan chimes in saying, CBD oil works for my friend's mother who has stage 4 cancer.  My friend is ultra straight and would never ever have anything to do with marijuana.  But he would try CBD because he was in full desperation mode, had heard many good stories, and learned that CBD is not psychoactive.  Mom had undergone chemo, her immune system was so compromised that the prognosis was death from chemo, if she continued.   Joe's friend reported that in two months, the cancer mass was reduced by 30%, her pain went away, and she could sleep.   Joe says, there are so many stories out there now, miracles, fairy tales that you have to try it.  Then when you think about it, the government is depriving cancer sufferers from a medicine that is very effective with almost no bad side effects. It makes you so fucking angry when we have these assholes working for the government making laws against Cannabis, for no purpose other than to cater to lobby groups and big corporations who manipulate the laws for their benefit and fuck the public.  The enemies of marijuana are actively trying to suppress information, slander and intimidate people.  One of the best ways to heal people, they're keeping it illegal, and act is criminal.  It's the government that is criminal doing a fucking horrible crime. In another case, the fighter had friend that was terminal with cancer.  So they asked the doctor if he could try marijuana.  The doctor said sure, we can prescribe Marinol, which is a synthetic form of THC.   The fighter asked, why didn't you recommend marijuana in the first place.  Doctor's answer: We're not allowed to.  Both Joe and the fighter agree that the synthetic marinol is not nearly as good as the real thing, it's just another way for the pharmaceutical industry to fuck things up.   THE FIGHT AFTER DAD DIES The fighter also lost his nephew the same night his father died.  All of this two weeks before a fight, a fight, if won, might pay for his son's entire university education, or pay off the mortgage on the house.  His coach gave Joe a pep talk.  Not the kind of pep talk that a pro coach dreams up to psyche up a multi-million dollar contract athletes.  It is the kind of talk that is real and matter of fact.  If Joe does not get his head together, he could end up with brain damage and a ruined career.  Who's going to take care of him and his family.  It is no fun walking around with concussion syndrome for months or years.  This is a moment shared by those who have to go into a life or death battle, no matter the weather.  Coach told him, what would your family want right now.  What do you want right now?  Do you want to cry about it.    Joe knocked our his fearsome foe, who was not too badly hurt and lived to fight another day too. It is life as we know it.  We have to stand up and handle life, but the added man made stress on top, over taxation and over regulation, the intrusion on freedom, the chemicals in food, cosmetics, the crooked bankers and corrupt government.  All of this is not our birthright.       Right now, at the core of the MMA movement is some real freedom fighters who are standing up for thing like medical marijuana. How about you?   FURTHER READING The many ways CBD inhibits cancer.    Br J Pharmacol. 2012 Nov;167(6):1218-31. doi: 10.1111/j.1476-5381.2012.02050 This study reveals that CBD inhibits angiogenesis by multiple mechanisms. Its dual effect on both tumour and endothelial cells supports the hypothesis that CBD has potential as an effective agent in cancer therapy. CBD, a potential anticancer drug PLoS One. 2013;8(1):e54795. doi: 10.1371/journal.pone.0054795. Epub 2013 Jan 22. Our findings support that THC- and CBD-loaded microparticles could be used as an alternative method of cannabinoid delivery in anticancer therapies. Cannabidiol inhibits cancer cell invasion Biochem Pharmacol. 2010 Apr 1;79(7):955-66. doi: 10.1016/j.bcp.2009.11.007. Epub 2009 Nov 13. these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers. Marijuana Fights Cancer and Helps Manage Side Effects, Researchers Find MARTIN A. LEE Evidence shows ‘cannabinoids’ in marijuana slow cancer growth, inhibit formation of new blood cells that feed a tumor, and help manage pain, fatigue, nausea, and other side effects. Antitumorigenic targets of cannabinoids - current status and implications Expert Opin Ther Targets. 2016 Oct;20(10):1219-35.doi:10.1080/14728222.2016.1177512. Epub 2016 May 11. Drugs aiming at the endocannabinoid system may represent potential 'antimetastatic' for an upgrade of a future armamentarium against cancer diseases. The influence of biomechanical properties and cannabinoids on tumor invasion Cell Adh Migr. 2016 May 5:1-14. [Epub ahead of print] Here we could show that a "generalized stiffness" is a profound marker for the invasiveness of a tumor cell population in our model and thus might be of high clinical relevance for drug testing. Additionally cannabinoids were shown to be of potential use for therapeutic approaches of glioblastoma.   MORE ON JOE SCHILLING AND JOE ROGAN Joe Schilling discusses death of father (from Joe Rogan Experience Joe Rogan and Joe Schilling Fighting  

SHARE YOUR PAIN - ARTHRITIS PATIENTS TALK MARIJUANA

Grab a large cup and settle down in your favorite reading chair.  The chances are you'll find come across someone in the same age bracket, with the same symptoms and condition.  If you find someone with interesting things to say, why not reach out and send a message, ask a question or even become a friend.  Just click on the blue text and you'll connect immediately via Facebook.   Without further ado, we bring you a composite of several major conversations from the Facebook matrix... about Marijuana and Rheumatoid Arthritis.   RA Chicks : Women with Rheumatoid Arthritis Member submitted response by message:   Wende Harris Winchester Here is my opinion, I have smoked it for years illegally most of the time, since dx of RA and Lupus and several other diseases. I take several medications and because of all the medications I suffer from insomnia. I smoke pot now because it relaxes me...See More ·  · 24 · March 9, 2014 at 7:17pm 1   Lisa Krusky Tate I live in British Columbia and joined a medical dispensary this year after doing some research.. I use a CBD tincture (drops under the tongue), marihuana honey for my tea, and a topical hash cream... They're all helpful and not intoxicating. They have lots of edible products and strains you can smoke, but I was looking for relief from pain and inflammation without the high. ·  · 9 · March 9, 2014 at 8:49pm Diane Miller Fuller it won't kill your liver  most meds. just saying! ·  · 14 · March 9, 2014 at 6:42pm Carrie Seibel It may help with the SYMPTOMS, but not the RA itself. There is a difference ·  · 7 · March 9, 2014 at 6:12pm Debbie Schroder Apperson It does stop the progression of RA. Read this article of research. http://norml.org/library/item/rheumatoid-arthritis. ·  · 6 · March 9, 2014 at 8:04pm · Edited Cathy Totino Barrett It is legal (if prescribed by a doctor) in Ontario, Canada. It works. I had a reverse shoulder replacement February 28th and since using the pot (I smoke) it has reduced the pain and has allowed me to not use the pain meds as much. Since using right ...See More ·  · 6 · March 9, 2014 at 7:24pm Dana Sebek i'm a cancer nurse with RA, and our patients talk about using it all the time, especially for nausea. I don't ask of course where they get it, as our state is not set up to do it. Having never smoked a cigarette, I wonder if the high is just an escape...See More ·  · 6 · March 9, 2014 at 6:13pm 3 Replies Paloma Maciel i live in mexico and even if t is not legal you know you can get it and i can say yes yes yes it does help also a friend of mine made a sort of alcahol mixed with marijuana and y rub it on my knees and arms when im having a bad day and it does help alot!!! ·  · 5 · March 9, 2014 at 7:02pm   Mary L Aull I use it for pain, it works & compared to the rx poisons, there is no problem ·  · 8 · March 9, 2014 at 6:09pm Stacee Meters I use it and get relief. ·  · 4 · March 9, 2014 at 11:55pm Rebecca Bratt Also, to the people saying it only is for pain and doesn't help the actual problem (ahem, Carrie seibel).. Wrong! Cannabis works to regulate your immune system. It also is an anti inflammatory. I have seen my swelling go down as a result of cannabis. It DOES reduce inflammation and autoimmune activity. And again, also helps with side effects (can't imagine taking mtx without it)! ·  · 4 · March 9, 2014 at 10:17pm Julie Kirtley I have found it to be very effective. Now that some states have legalized it there is more consistency with what you are dosing. Pain is minimized and sleep is possible ·  · 4 · March 9, 2014 at 8:24pm Denice Howard to each her own...accentuated my bad spots....were I to use again it would be solely for the purpose to help me forget, even only momentarily that I suffer this stupid illness!!!! LORL ·  · 4 · March 9, 2014 at 6:58pm · Edited Tiffany Staats Considering all of the dangerous prescription medications we already use to treat RA and our other various autoimmune diseases, the side effects of medical marijuana hardly seem  an issue worth worrying about. We can inject chemo into our bodies on...See More ·  · 3 · March 10, 2014 at 8:31am Angie Wink O'Connell "Joints for joints" study results. http://www.arthritistoday.org/.../medical-marijuana.php ·  · 3 · March 9, 2014 at 10:12pm Cheryl Goldstein Cirko-Hill I'm in pain 24/7. I've had 5 spinal fusions, hip and knee surgery and will be scheduling my 2nd ankle surgery soon. unfortunately i am fatally allergic to All forms of morphine, oxy, percocet etc. . I would try almost anything to help relieve pain incurred by RA and post surgery; but it is not legal in my state, hmmm. maybe I need to move! any suggestions? ·  · 3 · March 9, 2014 at 9:56pm Angie Rios Vallejo Biologics may slow down the progression but the side effects are horrible. Many times increased joint pain and swelling was a side effect. I would consider medical marijuana. It is no fun to be in pain. Sleepless nights, having to call in sick, not being able to do all the things I used to do due to the pain is a legitimate reason for me to say that yes, I would try it if it was legalized in my state. ·  · 3 · March 9, 2014 at 8:29pm Kathy Lindsay Joyce Legal in Washington State now. People say edibles are the way to go for Methotrexate nausea not sure about the pain. Doing my research for now. ·  · 3 · March 9, 2014 at 6:36pm Rebecca Ortolano Mancini I know people that use it for RA and swear by it. They don't smoke it, they drink it  a tea. It is not legal where I am. ·  · 3 · March 9, 2014 at 6:26pm Julia Jewels King I used it for years and years thinking it was helping. it is illegal in the UK so I could only get the smoke able stuff. When i finally gave up because I quit smoking I realised that physically it had made no difference at all. it had relaxed me but it...See More ·  · 3 · March 9, 2014 at 6:13pm 5 Replies Jeni Champlin I smoke and it helps me tremendously. .. pills just make me a zombie ·  · 2 · March 10, 2014 at 1:15pm 1 Giselle Macedo It works really well and in small portions it doesn't make you high. Much better than any pain killer! ·  · 2 · March 9, 2014 at 11:21pm Rebecca Bratt Marijuana helps me accomplish things that I would otherwise be in too much pain to.. Without the gi problems most pain killers bring! Also helps me eat when I'm on drugs that make me nauseous and/or lacking appetite. ·  · 2 · March 9, 2014 at 10:12pm Angie Wink O'Connell Effects of Indica (lower THC, higher CBN/CBD): Indica generally more physical than cerebral (however, the relief of physical symptoms can have a positive psychological effect) Sedation, pain relief and relaxation ...See More ·  · 2 · March 9, 2014 at 9:47pm Mirah Riben Relieving the symptoms does not stop the progression of the disease which leads to crippling and deformities. Biological do both - relieve the pain and swelling and stop the progression. ·  · 2 · March 9, 2014 at 7:42pm 2 Replies Debbie McCormick I'm in RI and it's legalized for Medicinal Purposes, I've had my license for 5 years now and don't know that I'd ever stop using it! I'm opiate dependent though can alter my daily intake with marijuana, my pcp was the first to suggest it, most of my spe...See More ·  · 2 · March 9, 2014 at 7:34pm Shelly Fazekas Privett I have tried it and found that it gives me a panic attack. It was kind of disappointing because I have heard from other users that it does work for the pain. ·  · 2 · March 9, 2014 at 6:49pm 3 Replies Noverta Davis-Dean I'm all for it if it helps live with the pain ·  · 2 · March 9, 2014 at 6:23pm Michel Winterburn The only thing it could help with is pain. When I was younger and smoked it, it only made my pain worse, it's  I would fixate on the pain. But really it's a personal thing. It'll work for some not for others. ·  · 2 · March 9, 2014 at 6:19pm Arlene Molina Jeni, did u get it medically. If so how is the process. ·  · 1 · March 10, 2014 at 1:53pm Arlene Molina I was thinking the same if it's effective ·  · 1 · March 10, 2014 at 1:52pm Kai Collins-Frazer If it is high in CBD it does help (Doesn't give your the "high" just the benefit) However  ALL medications... it only treats the symptoms. There is NO cure for RA, there is just therapies. The reason those of us who were on meds... have sought other resources. Without the side effects that damage the rest of our body- MTX, Plaq, Sulfa... and so on... ·  · 1 · March 10, 2014 at 3:00am · Edited Nilsa Avalo im a mom of a person with ra- i have never smoke it , i have smelled it and it gives me headaches. Weird- everyone is different, but if it makes my child feel better then yes. If it was for recreational purposes of course not i wouldn't allow it. But she is a young adult so i would let her make that decision on her own but with her knowledge that i personally don't approve. ·  · 1 · March 10, 2014 at 2:58am Mar Eds i tried smoking it back in the day but never d it. i would love to try the edible form though. i'm from canada and it's legal, but my rheumy would never go for that. he loves that i take celebrex for the pain. sigh. but he doesn't know i rarely if...See More ·  · 1 · March 9, 2014 at 10:35pm · Edited 4 Replies Patsy Horton Cheryl Goldstein Cirko it's legal in Colorado.. ·  · 1 · March 9, 2014 at 10:10pm Pamela Skidmore Hill From what I understand medical marijuana is great for pain. That is the pills. If they made it legal here in VA I would use it for pain and not feel guilty. ·  · 1 · March 9, 2014 at 9:58pm 1 Barbara Godshall Interesting to read the comments. I wouldn't smoke it I feel horrible around any smoke. Even the wood burner in the basement family room I can't stand. Capsules or a rub that might be different if approved in our state. I wouldn't judge anyone for ...See More ·  · 1 · March 9, 2014 at 9:35pm · Edited Kim Larsen AMAZING what it did to my pain levels... If you take a very small dose it will completely take away the pain and not make you high... I am very careful with it... Only use it when in a lot of pain and in very small doses... ·  · 1 · March 9, 2014 at 9:06pm 1 Cheryl Dalla-Vicenza Juice it, or take it in a capsule then you get the pure cannabis that is how you get optimal pain relief. Smoking it makes you high and isn't so good for your lungs. ·  · 1 · March 9, 2014 at 7:22pm Paula Jones It can be just as effective as any other narcotic with similar effects to Vicodin or Percocet. ·  · 1 · March 9, 2014 at 7:19pm Karen Tutcher Austin I have a relative who says it's the only thing that helps with the pain of RA. She has no insurance, therefore, no meds. ·  · March 10, 2014 at 10:05pm Tanya Gerrard I have suffered for 16yrs with RA and spent the last two smoking weed only as bio's (enbrel) stopped working after 7rys.. Cimzia put me on my back for a yr sicker then a dog.. and mtx.. don't even get me started. the weed doesn't treat anything but gives you an appetite.. and helps with pain.. and being able to sleep.. I can now move my arm over my head.. and I've had less flares.. but best of luck to you.. ·  · March 10, 2014 at 6:52pm Jeni Champlin Arlene Molina no I don't have a prescription. .. but I am lookin to move where I could get it. .. it really does help. . ·  · March 10, 2014 at 3:10pm Angie Wink O'Connell Arlene Molina Here is the link regarding NJ mmj laws http://new-jersey.medicalmarijuana.net/.../understanding.../ ·  · March 10, 2014 at 2:31pm Donia Hunter As a young adult of the 1960's who lived in California I am quite familiar with marijuana and its ability to alter feelings of all sorts. The question that begs that I haven't seen addressed anywhere is what is the possible damage to the body when it is ingested or smoked daily?. Do we know? Obviously smoking it daily will do a number on the lungs; what about eating it? Anyone know? ·  · March 10, 2014 at 9:10am · Edited Doreen Meyer It helps me sleep thru all the aches and pains. I got a medical card before it was legal for everyone in my state... ·  · March 10, 2014 at 2:53am Cynthia Butler Marsch I don't use it but my friends who know I have RA, strongly suggest it. They said in California, they dispense it in a lotion form. I

CANNABIS TRENDING TO #1 - INFLAMMATION & AUTOIMMUNE DISEASE

  " According to the National Institute of Pain, Cannabis has 20 x the antiinflammitory power of Asprin."    A doctor hesitated in prescribing CBD to a patient with an autoimmune disorder, that same patient was taking a gigantic cocktail of pharmaceuticals, including pregnenolone.  The Doc said, CBD works, but we don't know enough about it.  After picking our jaw up off the floor, to tame the ignorance, we set about writing of this article, which references about one hundred research reports - relating to solely to cannabis and inflammation -  from renowned institutes from across the planet.   CANNABINOIDS - THE BEST SOLUTION TO INFLAMMATION - RIGHT NOW?   Cannabinoids modulate the two types of receptors found in immune system cells that control inflammation Cannabinoids can increase programmed cell death in immune T cells Studies show that THC, THCV, CBD attenuate (dial down) both receptors that control immune response Cannabinoids have a very lower level of toxicity THC and CBD are better tolerated than steroids and other pharmaceuticals, by a very wide margin A google, medical literature search reveals no cases of malpractice involving THC, CBD or other cannabinoids Several cannabinoids show anti-bacterial, antiviral, and antimicrobial properties Cannabinoids interacts can contradict or complement other medicines     WILL CANNABINOIDS BECOME THE NUMBER ONE ANTI-INFLAMMATORY DRUG? Cannabinoids are defined medically as a substance that attenuates or moderates the body's cannabinoid receptors.  There are two main cannabinoid receptors that have been studied thus far.  The CB1 receptor is greatly affected by psychoactive d9THC, the main ingredient of most types of American marijuana.   In fact, the discovery of THC itself led to the discovery of the cellular receptor system, hence the name.  The CB1 receptor is predominant in the brain and nervous system while the CB2 receptor is found predominantly in the cells that comprise the immune system.  The cannabinoid CBD interacts powerfully with the CB2 receptor with only a minor effect on the CB1 receptor.  Later it was discovered that both CB1 and CB2 receptors have reside in immune cells, which explains why so many cannabinoids affect and modulates the immune response.   "Most research focuses on the generall efficacy of Cannabis, THC and CBD.  It is virtually certain that an individualized custom mix of with other cannabinoids and terpenes in varying ratios stands to greatly amplify the therapeutic effect in inflammation and other conditions.  This concept is very exciting to both sufferers and researchers of auto-immune diseases alike."   Recently, research studies have demonstrated that suggests THC and other cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that the administration of THC in mice triggered apoptosis - cell death in rogue immune T cells and dendritic cells, which resulted in immunosuppression.  Interestingly, the same cannabinoids that suppress immune response also exhibit antimicrobial properties simultaneously.   "Cannabinoid receptor trafficking in immune cells is dynamically regulated by a binary biochemical switch and ingredients in marijuana such as THC and CBD." - Biochemical Pharmacology   In addition, cannabinoids were shown to downregulate infection-signaling chemical production; of both cytokine and chemokine.  The role of the body's own endocannabinoid system is also involved in immunoregulation and erratic delivery or overproduction of the body's endocannabinoids is thought to lie at the core of errant immune response / disease. The administration of endocannabinoids of enzymes that break down the endocannabinoids, was shown to lead to immunosuppression and recovery from immune-mediated injury.  Manipulation of the endocannabinoid system (agonist and antagonist) using cannabinoids may offer better and safer treatment of inflammatory disorders, due to their especially low toxicity in mammals.     420EvaluationsOnline:  Patients in California and Nevada still require a medical doctor's recommendation to buy either Recreational or Medical Marijuana in California. until at least 2018.  Thanks to the Medical Board of California, 420 Evaluations, Cannabis ID Cards and Grower's permits can be approved over the internet using our Telemedicine compliant process.  Our medical cannabis documents are accepted by clinics, conpassion clubs, cannabis dispensaries, marijuana delivery services and law enforcement in both California and Nevada.  The process is same day, completed 100% online, and takes only ten minutes to complete.  Patients don't have to pay until they're approved to legally buy, possess, transport and use MMJ.  Get Started here.   FURTHER READING - A LOT OF RESEARCH ABOUT WHAT IT DOES Inflammation & Medical Marijuana  An introduction to Cannabis and Inflammation    A wealth of Testimonials and Research Articles that attest to the Benefits of Cannabis in treating Many Kinds of Inflammation.   Cannabinoids as novel anti-inflammatory drugs Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress   The endocannabinoid system: an emerging key player in inflammation Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice   Cannabinoids, endocannabinoids, and related analogs in inflammation   Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors   Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis   Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation   Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement   Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption   Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the non psychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation   Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death Cannabinoids in clinical practice   Pure THC-V inhibits nitrite production in murine peritoneal macrophages Cannabinoids, inflammation, and fibrosis Inflammation - Project CBD Inflammation – Medical Marijuana Research Overview Why Cannabis Stems Inflammation Hemp Oil For Inflammation – Studies Show Benefits of Cannabinoids  ETH Zurich/Swiss Federal Institute of Technology Cannabinoids, inflammation, and fibrosis Robert B. Zurier1 and Sumner H. Burstein Department of Medicine University of Massachusetts Medical School, Worcester, Massachusetts; and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts USA Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis. Fitoterapia116, 77-84. Sabrina Giacoppo, Federica Pollastro, Gianpaolo Grassi, Placido Bramanti, Emanuela Mazzon. (2017) Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. Journal of Neuroinflammation 13:1. Ewa Kozela, Ana Juknat, Fuying Gao, Nathali Kaushansky, Giovanni Coppola, Zvi Vogel. (2016) Therapy implications of the role of interleukin-2 in cancer. Expert Review of Clinical Immunology, 1-8. Paolo Lissoni. (2016) Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy. Molecules 21:10, 1252. Gihyun Lee, Sun Kim. (2016) Docosahexaenoic acid attenuates in endocannabinoid synthesis in RAW 264.7 macrophages activated with benzo(a)pyrene and lipopolysaccharide. Toxicology Letters258, 93-100. Joanna Gdula-Argasi?ska, Beata Bystrowska. (2016) Host factors associated with serologic inflammatory markers assessed using multiplex assays. Cytokine 85, 71-79. Heather S. McKay, Jay H. Bream, Joseph B. Margolick, Otoniel Martínez-Maza, John P. Phair, Charles R. Rinaldo, Alison G. Abraham, Lisa P. Jacobson. (2016) Challenges to develop novel anti-inflammatory and analgesic drugs. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. Bálint Botz, Kata Bölcskei, Zsuzsanna Helyes. (2016) Anti-Inflammatory and Osteoprotective Effects of Cannabinoid-2 Receptor Agonist HU-308 in a Rat Model of Lipopolysaccharide-Induced Periodontitis. Journal of Periodontology 87:6, 725-734. Cesar A. Ossola, Pablo N. Surkin, Claudia E. Mohn, Juan C. Elverdin, Javier Fernández-Solari. (2016) Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3-L1 Preadipocyte Cell Line. Journal of Cellular Physiology231:2, 483-489. Valeria Tutino, Antonella Orlando, Francesco Russo, Maria Notarnicola. (2016) Marijuana Legalization: Impact on Physicians and Public Health. Annual Review of Medicine 67:1, 453-466. Samuel T. Wilkinson, Stephanie Yarnell, Rajiv Radhakrishnan, Samuel A. Ball, Deepak Cyril D'Souza. (2016) HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells. Chemical Biology & Drug Design 87:1, 143-153. Ewa Kozela, Christeene Haj, Lumir Hanuš, Mukesh Chourasia, Avital Shurki, Ana Juknat, Nathali Kaushansky, Raphael Mechoulam, Zvi Vogel. (2016) For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 64, 167-180. Rebecca J. Henry, Daniel M. Kerr, David P. Finn, Michelle Roche. (2016) Asthma Associated with the Use of Cocaine, Heroin, and Marijuana: A Review of the Evidence. Journal of Asthma, 00. Timothy H. Self, Samarth Shah, Katherine L. March, Christopher W. Sands. (2016) Downstream effects of endocannabinoid on blood cells: implications for health and disease. Cellular and Molecular Life Sciences 72:17, 3235-3252. Valeria Gasperi, Daniela Evangelista, Isabella Savini, Domenico Del Principe, Luciana Avigliano, Mauro Maccarrone, Maria Valeria Catani. (2015) Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor. Scientific Reports 5, 10682. Lewis Taylor, Ivy Christou, Theodore S. Kapellos, Alice Buchan, Maximillian H. Brodermann, Matteo Gianella-Borradori, Angela Russell, Asif J. Iqbal, David R. Greaves. (2015) Psychiatric Symptoms, Salivary Cortisol and Cytokine Levels in Young Marijuana Users. Journal of Neuroimmune Pharmacology 10:2, 380-390. Christine C. Cloak, Daniel Alicata, Thomas M. Ernst, Linda Chang. (2015) Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation. Journal of Neuroimmune Pharmacology 10:2, 333-343. Michael D. Roth, Julie T. Castaneda, Sylvia M. Kiertscher. (2015) Epigenetic Regulation of Immunological Alterations Following Prenatal Exposure to Marijuana Cannabinoids and its Long Term Consequences in Offspring. Journal of Neuroimmune Pharmacology 10:2, 245-254. Elizabeth E. Zumbrun, Jessica M. Sido, Prakash S. Nagarkatti, Mitzi Nagarkatti. (2015) Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation. International Journal of Molecular Sciences 16:4, 7057-7076. Eleonora Patsenker, Philip Sachse, Andrea Chicca, María Gachet, Vreni Schneider, Johan Mattsson, Christian Lanz, Mathias Worni, Andrea de Gottardi, Mariam Semmo, Jochen Hampe, Clemens Schafmayer, Rudolf Brenneisen, Jürg Gertsch, Felix Stickel, Nasser Semmo. (2015) Δ 9 Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells. British Journal of Pharmacology 172:7, 1792-1806. R Rao, P S Nagarkatti, M Nagarkatti. (2015) Central administration of GPR55 receptor agonist and antagonist modulates anxiety-related behaviors in rats. Fundamental & Clinical Pharmacology 29:2, 185-190. Abbasali Rahimi, Akbar Hajizadeh Moghaddam, Ali Roohbakhsh. (2015) Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model. Brain Research 1602, 127-135. Yihao Tao, Jun Tang, Qianwei Chen, Jing Guo, Lin Li, Liming Yang, Hua Feng, Gang Zhu, Zhi Chen. (2015) Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. Journal of Neuroinflammation 12:1, 52. Ewa Kozela, Ana Juknat, Nathali Kaushansky, Avraham Ben-Nun, Giovanni Coppola, Zvi Vogel. (2015) New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids. International Review of Cell and Molecular Biology, 43-116. Robert Ramer, Burkhard Hinz. 2015. FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. Journal of Neuroimmunology 276:1-2, 126-134. Rebecca J. Henry, Daniel M. Kerr, David P. Finn, Michelle Roche. (2014) Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical Pharmacology92:2, 312-325. Maria Haustein, Robert Ramer, Michael Linnebacher, Katrin Manda, Burkhard Hinz. (2014) Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. Journal of the Neurological Sciences 342:1-2, 101-106. Mutsumi Fujii, Prativa Sherchan, Paul R. Krafft, William B. Rolland, Yoshiteru Soejima, John H. Zhang. (2014) Adverse Health Effects of Marijuana Use. New England Journal of Medicine 370:23, 2219-2227. Nora D. Volkow, Ruben D. Baler, Wilson M. Compton, Susan R.B. Weiss. (2014) Simultaneous ultra-high performance liquid chromathograpy-electrospray ionization-quadrupole-time of flight mass spectrometry quantification of endogenous anandamide and related N-acylethanolamides in bio-matrices. Journal of Chromatography B 958, 83-89. Roberta Ottria, Alessandro Ravelli, Fausto Gigli, Pierangela Ciuffreda. (2014) Vitreous biomarkers in diabetic retinopathy: A systematic review and meta-analysis. Journal of Diabetes and its Complications 28:3, 419-425. Annie K. McAuley, Paul G. Sanfilippo, Alex W. Hewitt, Helena Liang, Ecosse Lamoureux, Jie Jin Wang, Paul P. Connell. (2014) Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro. European Journal of Pharmacology 721:1-3, 133-140. Zili Zhang, Yao Guo, She Zhang, Yan Zhang, Yuqing Wang, Wenxia Ni, Desong Kong, Wenjing Chen, Shizhong Zheng. (2013) Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype. Journal of Neuroimmune Pharmacology8:5, 1265-1276. Ewa Kozela, Ana Juknat, Nathali Kaushansky, Neta Rimmerman, Avraham Ben-Nun, Zvi Vogel. (2013) Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders. Journal of Autism and Developmental Disorders 43:11, 2686-2695. Dario Siniscalco, Anna Sapone, Catia Giordano, Alessandra Cirillo, Laura de Magistris, Francesco Rossi, Alessio Fasano, James Jeffrey Bradstreet, Sabatino Maione, Nicola Antonucci. (2013) Immunosuppressive and anti-inflammatory effects of N-acyl dopamines on Con A-stimulated splenocytes of BALB/c mouse. European Journal of Lipid Science and Technology 115:11, 1284-1293. Mei Chen Jin, Xi-Wen Liu, Mee Ree Kim, Dai-Eun Sok. (2013) Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy 68:8, 994-1000. E. Gaffal, M. Cron, N. Glodde, T. Tüting. (2013)   The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. British Journal of Pharmacology 169:4, 808-819. DM Kerr, B Harhen, BN Okine, LJ Egan, DP Finn, M Roche. (2013) The role of CB1 in immune modulation by cannabinoids. Pharmacology & Therapeutics 137:3, 365-374. Barbara L.F. Kaplan. (2013) Interleukin-17 in post-stroke neurodegeneration. Neuroscience & Biobehavioral Reviews 37:3, 436-447. Walter Swardfager, Daniel A. Winer, Nathan Herrmann, Shawn Winer, Krista L. Lanctôt. (2013) The role of endocannabinoids in pain modulation. Fundamental & Clinical Pharmacology 27:1, 64-80. Panagiotis Zogopoulos, Ioanna Vasileiou, Efstratios Patsouris, Stamatios E. Theocharis. (2013) Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. Cellular Signalling 25:2, 501-511. Y. Yang, H. Yang, Z. Wang, K. Varadaraj, S.S. Kumari, S. Mergler, Y. Okada, S. Saika, P.J. Kingsley, L.J. Marnett, P.S. Reinach. (2013) RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expression. Immunobiology 218:1, 40-51. Stephanie Ley, Andreas Weigert, Jean-Karim Hériché, Blandine Mille-Baker, Richard A.J. Janssen, Bernhard Brüne. (2013) The molecular connections between the cannabinoid system and endometriosis. Molecular Human Reproduction 18:12, 563-571. A. M. Sanchez, P. Vigano, A. Mugione, P. Panina-Bordignon, M. Candiani. (2012) Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. Glia 60:11, 1629-1645. Gopinath Krishnan, Nivedita Chatterjee. (2012) Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats. Inflammation Research 61:9, 941-948. Cesar A. Ossola, Pablo N. Surkin, Antonela Pugnaloni, Claudia E. Mohn, Juan C. Elverdin, Javier Fernandez-Solari. (2012) Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB 1 Receptor. Journal of Medicinal Chemistry 55:11, 5627-5631. Francesco Piscitelli, Alessia Ligresti, Giuseppe La Regina, Antonio Coluccia, Ludovica Morera, Marco Allarà, Ettore Novellino, Vincenzo Di Marzo, Romano Silvestri. (2012) “Redundancy” of Endocannabinoid Inactivation: New Challenges and Opportunities for Pain Control. ACS Chemical Neuroscience 3:5, 356-363. Fabiana Piscitelli, Vincenzo Di Marzo. (2012) Jonas Kleyer, Simon Nicolussi, Peter Taylor, Deborah Simonelli, Evelyne Furger, Pascale Anderle, Jürg Gertsch. (2012) Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochemical Pharmacology 83:10, 1393-1412. Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation. Journal of Inflammation 8:1, 33. Ravi Murumalla, Karima Bencharif, Lydie Gence, Amritendu Bhattacharya, Frank Tallet, Marie-Paule Gonthier, Stefania Petrosino, Vincenzo di Marzo, Maya Cesari, Laurence Hoareau, Régis Roche. (2011) Cannabinoids: novel therapies for arthritis? 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CRAPPY WEED - 5 THINGS YOU NEED TO LOOK FOR

  "Do you know what you're doing?  If you don't have someone you can trust, it is best that you take the law into your own hands, and learn the simple 5 item quality control cannabis checklist."    When you go into a dispensary it is good to consult with a knowledgeable budtender.  Even if your cannabis professional knows their stuff, everyone has a bad day, or has too many things to do, so you might be left holding a bag of grotty weed. Cannabis can have a very long shelf life, provided that it is stored correctly, in dry conditions, preferably in air tight glass containers.  If your marijuana provider pulls out a dusty bottle from the top shelf and the seal is obviously not good, right there, you don't want that weed, at any price.  If Cannabis is to stand the test of time, it needs to be grown and harvested properly, without mold, insects, chemical sprays and other undesirables.  This means that your dispensary knows which suppliers produce quality cannabis.   If everything is perfect, then cannabis can keep for 10 years or more.  Recently, containers contain a non-toxic desiccant and container is sealed with an argon gas purge.  Argon is an entirely inert gas that exists naturally in the atmosphere and stops oxidization.  But if cannabis is dry, chemical and mold free, a portion of THC can oxidize and two hydrogen bonds break.  This new-old molecule is called cannabinol.  Cannabinol has different psychoactive and medicinal properties, some of which is preferable.  So properly aged cannabis might be compared to a fine vintage of wine .... that has not turned into vinegar!   THE FIVE KEY QUALITY INDICATORS AROMA   Good weed smells good.  Bad weed, not. Weed's aroma comes from its volatile components, small molecules that easily evaporate into the air.  Most of these aromatic compounds are terpenes and thiols.  Terpenes mixtures have a characteristic smell.  The fragrance of lime, orange, mint, pine, pineapple.... and cannabis, is nearly all from the terpene composition.  Thiols are particularly smelly and account for the skunk odor of many cannabis varieties.  Basically, if the smell is very pungent, is wickedly strong, then that weed is likely well preserved or fresh.   If the weed smells moldy, it probably is.  But you need to be able to distinguish the mold smell from earthy aromas that certain strains possess.  In this regard, sniffing out bad weed is a skill similar to a wine tasters ability to analyze the bouquet of fine wines. Certain smells don't belong there, if you smell something you've never smelted in weed before, like, say rotting fish, you want to ask questions.  Without a proper explanation from a verified expert, don't buy weed that does not smell right to you, even if you're new to the game. VISUAL Good potent weed has a lot glossy of trichomes What does crappy weed look like?  In the case of fruit and vegetables, looks can be very misleading.  Artificial ripening, overspraying to make them blemish free, overhydration and other tricks make the produce excellent, but it can taste like ass.  Not only that, it's hazardous to your health.  With that said, there are tell tale signs that are a sure sign that things are not A-OK. Old and dried out cannabis is crunchy and break apart into a fine powder. Seeds and stems are necessarily indicative of bad cannabis, but its a small red flag, you want to look deeper. Mold and Trichomes look similar but under the magnifying glass trichomes are glassy crystal like plant gadgets that contain much of the plant's medicinal chemicals, like the terpenes, THC, CBD and other cannabinoids. Moldy weed has cotton fibers growing out of the trichomes.     Mold Free   Mold City   TACTILE - HANDLE IT   Is it easy to pull the nugs apart or are they compressed (bad)?  Does the weed feel moist (bad). Does the weed fall apart to the touch (maybe old, but many ok).  When you get some really good weed, notice its texture and feel, and look for those traits into the future.  Also, strike up a conversation with a good budtender and ask for tips.  If he doesn't have any, then maybe you need to find a new place to buy your week.  We like our professionals to know more than us, right?   TASTE   Good weed tastes good, bad weed tastes like crap. It is good to do a little sniffing around to develop your ability and confidence.  Ask your local budtender to let you taste and smell some quality pot and some samples of lesser quality.  Or get in the habit of manhandling your mate's stash. At the end of the day, if your cannabis looks good, smells good, breaks apart with no issues, and gives you that wonderful snap sensation, try it out. If you haven’t taken the time to inspect your herb first, I don’t advise skipping straight to smoking it before determining if it’s old or bad. That said, bad cannabis does not smoke well, which you’ll figure out very quickly into your first puff. Sometimes you just have to dig in and give it a try (although you should, at the very least, inspect for mold first). AUDIO   No, we're not joking.  Properly cured and dried buds will make a crisp snap sound when the are pulled apart. A crisp sound means that the moisture content is low, which is good.  Overly moist buds are harder to pull apart and don't make much of a sound.  Snap, crackle, and pop, good.   “Weed makes you stupid, fat, and lazy and if you’re a girl you act like a whore?  Okay so I’ve been smoking weed since I was 11 and I have straight A’s, I weigh 120 lbs, I go for a run everyday, and I’ve been with the same guy for over a year. When is all that negative shit going to actually happen? All my friends seem to be the same way too and we all smoke a fuck ton" - Alpha Female Katie   AT THE END OF THE DAY   In addition having the weed passes your on-site testing, it is highly recommended ...to get a valid certificate of analysis that shows that your medical herb is free of chemicals, sprays, and provides potency information, percentages of the cannabinoids, especially the THC, and CBD.   It is quite useful to know the THCV values as well, because it's effects tend to work opposite to regular THC.  THCV is energising and suppress appetite as opposed to the sedating and munchie inducing THC.  THCV is also more uplifting while THC can make you paranoid.  Terpene test values are useful to find out what kinds work for you.  For the scientifically inclined, there are a million combinations and perturbations to study.   420EvaluationsOnline:  We specialize in Cannabis Recommendations using Telemedicine, a process encouraged by the Medical Board of California.  Telemedicine is the fastest, cheapest and most efficient way to complete routine medical evaluations and paperwork.  Our user friendly process takes a few minutes, is one hundred percent online, and is same day.  A 420 recommendation from a licensed doctor costs only $49, and Cannabis ID cards are a $20 add on. Your 420 Recommendation is accepted by licensed dispensaries, delivery services, law enforcement officers (state), cooperatives, cannabis clinics in the State of California and Nevada.   FURTHER READING   WHY SMOKING MOLDY WEED IS BAD, BAD NEWS If you thought smoking moldy Weed with a is no big deal, think again my friend...... "We raided 30 grow operations and took a  total of 407 fungal spore samples.......Two independent types of tests identified elevated fungal spore levels.......especially during the removal of plants from the Ops. In some cases, after plant removal, spore counts increased to levels above 50,000 spores,,,,,   HOW TO BUY MEDICAL MARIJUANA WISELY - ONLY FOOLS RUSH IN "Fool me once, shame on you, fool me twice, shame on me.  Or read this article and forget about who's shaming who." ........How to get Medical Marijuana legally in California and not get ripped off.  Right now, it is a bit of a free for all out there.  State and County laws are changing rapidly.   We share our experience from our on-line lives in Medical Marijuana consumerism here and answer the FAQs including: How can I legally buy Medical Marijuana in California? ....How can I get a Medical Marijuana Recommendation online?........How can I know if a provider is a scam artist?   MMJ DOCTOR THAT TESTED 15,000 POT SAMPLES SPEAKS Lab Tested Marijuana....Dr. Paul Hornby and the Three Way Split   “My driving force behind all of this is really discovery.” - Dr. Hornby   LAB TESTING MEDICAL MARIJUANA - TOXIC CHEMICALS AND MICROBES What should Medical Marijuana Growers Test For? - or - How can I Assure that MY Medical Marijuana is perfectly Safe? ......The basic objective of testing is to prove that the Herbal medicine in question - is both medically potent and toxin free......  Essential medicinal ingredients that should be quantified are the Cannabinoids THC and CBD......   Potentially harmful things to test definitely include Pesticides, Mold, Bacteria, and Mycotoxins (toxic microbe shit).    

CBD USER EXPERIENCE SHARE - HIGHLY RECOMMENDED

  We had to share this wonderful video about a regular Joe's experience with CBD.   VapnFagan says he takes a sleeps like a baby with CBD, and it controls his anxiety too.  He had a splitting headache that did not respond to Tylenol and other medications, but CBD did the trick.  So he's all in, and doubled down.  Click on the image to lbe educated on the basics about CBD.  But remember, everyone's experience is not the same, and there are many different kinds of cananbis based medicines that offer different medicinal and recreational experiences. COMMENTARY Alex Dodogne - Gained a lot of respect for you from this video brother . Thank you for showing people the real side of cannabis, great man , keep up the great work !? Jay White  Thank you this CHANGED my 55 year old moms life who has severe anxiety. She even stopped taking her Xanax. I have been on Xanax 3 bars (6mg) a day for 15 years and I would love it to stop. Seeing her effects (who doesnt drink or do anything) I am going to try this myself now.? Justin Franks +Jay White Just be sure to speak with your doctor and get a tapering schedule for the Xanax. Benzodiazepines are one of the few drugs whose withdrawal can kill you.? Lookingoodat381 CBD oil has changed my life! I suffer from bipolar disorder; therefore, the mania, depression, & anxiety is unbearable. I had a doctor's appointment to see a psychiatrist 2 weeks before I tried CBD oil. I didn't want to go on prescription meds due to the terrible side effects. I've tried every natural supplement known to man over the last 2 years & nothing worked. This is my 2 week on CBD oil & this is first time in 10 years that I was able to go to work without anxiety. I can also go out in public without suffering from social anxiety. It's just keeps me calm & relaxed. I was so happy that I was able to cancel my doctor's appointment. I recommend this to anyone & the price is not really that expensive. I pay $29.99 for CBD platinum & I still have some left after 2 weeks of use. So I can estimate it lasts about 3-4 weeks, which is not that bad as I originally thought.? wanna3737 do you vape it? I prefer vaping.? lonepanther I prefer to vape it because it works faster that way.?   420 EvaluationsOnline:  While VapnFagan got much of the science right, he was not clear on a couple of things.  You need a doctor's recommendation to purchase CBD that is derrived from tmarijuana - but not hemp.  Also, you cannot test positive for THC when you take CBD without THC, buit beware that there is a residual amount of THC in many CBD products.  Also, it is possible to botch the drug test and get a false positive.  If this happens, you can request a test using GCMS.  Also, athletes who test positive can be cleared if they were taking a product that does not show THC as an ingredient on the label.   So functionally, in California, Nevada and most of the other medical marijuana states, you'll need a recommendation from a medical doctor to buy CBD products.  You can have a doctor evaluate your conditions and symptoms, now  online, same day   Patients don't  pay unless they're approved.  420Evaluations Online also supplies Cannabis ID Cards, Grower's Permits as well as renewals.  Our documents are accepted in California and Nevada by state law enforcement, cannabis clinics, cooperatives, clinics, online dealers, dispensaries and delivery services.     FURTHER READING WHY YOU'RE PROBABLY SMOKING THE WRONG STRAIN Finding the Right Strain - Marijuana Basics Clarified....."Most Veteran Pot smokers think they know a lot about their weed, Not true, suggests our not so small unofficial survey of doctors, patients and recreational cannabis smokers.".....With the approval of your favorite medical professional, most everyone that medicate with cannabis should do the following: Buy marijuana with a certificate of analysis Try raw cannabis and hemp juicing CBD - THE BEST MEDICINE FOR YOUR HEART? CBD - The single best thing you can do for your heart?  "According to the mounting research evidence, CBD might be the single best thing you can do for your heart. " ....  CBD & Heart Disease  -  Q & A EPILEPSY: COMPLETE REMISSION with Purified CBD Will Cannabis Based Medicines make seizures extinct?  "Two children achieved full remission of Refractory Epilepsy after switching from an extract of intoxicating Δ9-THC to pure CBD (cannabidiol). Pure CBD extract ora Get Medical Marijuana Card Online | Medical Marijuana Doctor Get your medical marijuana card in 10 minutes online! Our Medical Marijuana Doctors offer Cannabis evaluations online! 420 Evaluations medical cannabis ... Marijuana and Inflammation - Medical Marijuana Doctor ... can help you with INFLAMMATION on 420 Evaluations Online. ... “CBD (FOUND IN MEDICAL MARIJUANA) works against pain primarily in the peripheral ... NAUSEA Symptoms and Treatments | 420 med evaluation online Medical marijuana research in NAUSEA has moved forward over the years. ... medical cannabis recommendation can help you with NAUSEA on 420 Evaluations Online. ... Cannabinoids include THC and CBD, that mimic naturally produced ... Pain - Medical Marijuana Doctor Check the Efficacy of Medical Marijuana in PAIN on 420 Evaluations Online. ... with treatment using the non-psychoactive Medical Cannabis component CBD.      

EPILEPSY: COMPLETE REMISSION with Purified CBD

  "Two children achieved full remission of Refractory Epilepsy after switching from an extract of intoxicating Δ9-THC to pure CBD (cannabidiol). Pure CBD extract oral led to complete seizure remission after 4 weeks." - Frontiers of Pharmacology - Paraphrase   CBD works in Epilepsy by stopping (modulating) neuromuscular receptors from misfiring. Animal studies and preliminary clinical trials strongly indicate that cannabidiol (CBD) in concentrated ethanol extract form have antiseizure properties in children with treatment-resistant epilepsy. However, since 1932, cannabis based medicines are not (as yet) re-registered as medicines for prescription by American regulatory agencies. In this study the cases of two children with treatment-resistant epilepsy is described.  In both cases, these children did not respond any prescription medicine: phenytoin, topiramate, carbamazepine, levetiracetam, lamotrigine, primidone, and clobazam. Case A has left frontal dysplasia Case B has Dravet Syndrome   Case A   A 10-year-old girl was diagnosed with refractory epilepsy as a baby of 5 months of age. Prior to cannabinoid treatment she had approximately three complex focal seizures. Treatment with phenytoin, topiramate, carbamazepine, levetiracetam, lamotrigine, primidone, and clobazam were ineffective, did not put seizures into remission.  The patient underwent focal resection of the left anterior frontal lobe at age 8 (Figure 1) and was seizure-free for 4 months.  She was dosed orally with CBD extract ( 208 mg/day or 6 mg/Kg/day; divided in three daily doses of 70 mg) with topiramate 1 mg/kg, clobazan 0.4 mg/kg and valproate 12.7 mg/kg. This mixture eliminated seizures and improved general behavior, speech, understanding, and attention. After 4 months she showed symptoms of psychological side effects, inappropriate laughter, ataxia, reduced attention, irritability, aggressiveness, spasms, bilateral mydriasis and  eye redness   An analysis of the extract showed about 4%Δ9-THC and 90% CBD, while hair analysis confirmed the ration of THC:CBD.  A 99.6 %  purity CBD extract was substituted with no measurable Δ9-THC.  Pure CBD extract oral showed no intoxication effect, as assessed by clinical evaluation and EEG results  Pure CBD extract oral led to complete seizure remission after 4 weeks.     "Surveys with caregivers and patients have also examined the effects of CBD-enriched extracts in epilepsy. One of such surveys involving parents of children with severe epilepsies in a Facebook group reported improvements in 16 out of 19 patients treated with CBD/Δ9-THC-enriched extracts, and two patients were reported to have become seizure-free"  - Study, Porter and Jacobson"   Case B   A 7-year-old boy had a diagnosis of refractory epilepsy due to SCN1A mutations associated with Dravet syndrome.  He had daily complex, focal, myoclonic, tonic, absence seizures and severe myoclonic epilepsy, He had substantial behavioral and developmental delays, hyperactivity and impulsiveness, and autistic-like symptoms. This boy was treated with anticonvulsant treatment stiripentol, valproic acid, oxcarbazepine, topiramate, levetiracetam, phenytoin, phenobarbital, and sulthiame. The boy was then given CBD extract oral 250 mg or 12.5 mg/Kg divided into two daily doses (125mg CBD); in addition to topiramate 3.75 mg/KG and valproate 24 mg/kg daily. Seizures then were reduced from 1–2 per day to once a month. General behavior, speech, understanding, and attention improved. After 3 months, he suffered from psychological issues; ataxia, reduced attention, irritability, aggressiveness, and seizure worsening. Analysis of the extract used showed a residual of about 3% THC, with 91% CBD.  Hair analysis confirmed the above THC:CBD ratios.  A 99.6 purity CBD extract, oral 200mg (100mg 2x daily) without measurable THC was substituted and the trial resumed. This dose was increased by 50% up to 300mg (150mg 2x daily).  The deletion of THC led to a complete reduction of all intoxication symptoms.  Complete seizure remission was achieved after three weeks. Autistic like symptoms were mostly eliminated.  The boy joined in school activities, socializing, swimming, sports.   FOLLOW-UP STUDY One year, both cases A and B were seizure free without intoxicating effects.  Dosage of CBD and pharmaceuticals (described above) were maintained throughout. Learn more about this study   "CBD-enriched treatment significantly reduced the frequency of seizures in most of the children (66/74, 89%) and only five (7%) patients reported seizure exacerbation that led to the discontinuation of treatment with CBD-enriched extracts. Despite this, minor and infrequent side effects were reported."     EPILEPSY & MEDICAL MARIJUANA Top 5 Medications for Seizures (Convulsions) - Epilepsy (2015)   Keppra Dilantin            Levetiracetam   Trileptal           Vimpat How Epilepsy Drug Side Effects Cause Death - Information and Statistics Keppra Toxic Effects : dizziness, drowsiness, feeling tired, weakness, feeling aggressive or irritable; loss of appetite, stuffy nose, infection. Source: www.drugs.com "After a three-month period, 261 Epileptic children, 50% experienced a reduction in seizures using oral Marijuana alone - with little to no side effects. In addition, Marijuana stopped seizures completely in a significant number of kids."  - Dr. Orrin Devinsky   DOCTOR TESTIMONIALS - HOW MEDICAL MARIJUANA TREATS EPILEPTICS SAFELY Charlotte, an epileptic, had been close to death so many times. She had substantial brain damage from seizures and very probably by the pharmaceutical medication. Charlotte and her parents.... Read more about Epilepsy and Marijuana 420EvaluationsOnline: Same day, 100% online medical marijuana doctor recommendations. If you want to buy cannabis based medicines containing CBD, such as strains; Mars OG, Grape Kush, Key Lime Pie, ACDC, Charlotte's Web, and Haley's Comet, in the State of California and Nevada, you're going to need a 420 recommendation by a licensed medical doctor.   Our documents are accepted by law enforcement, cannabis clubs, cooperatives, dispensaries and other MMJ product suppliers in both California and Nevada.  We also provide cannabis ID cards and growers permits.  Apply here today.   FURTHER READING 5 Highly Recommended Strains For Epilepsy    

CBD - THE BEST MEDICINE FOR YOUR HEART?

"According to the mounting research evidence, CBD might be the single best thing you can do for your heart. "   CBD & Heart Disease  -  Q & A   Is the cardiovascular system a therapeutic target for CBD by medical researchers?   Yes   Is there clinical evidence that CBD is beneficial in an assortment of cardiovascular conditions. Yes   Is CBD legal in the US? Yes, but only if it is extracted from Hemp and not Marijuana   The FDA of the United States considers hemp oil (and its derivative CBD) to be a dietary supplement (not a medication), since they are made from industrial hemp plants. If you live in the US, this means you don't need a prescription and can legally purchase and consume Cannabidiol in any state.   "Accumulating evidence now also suggests that CBD is extremely beneficial in the cardiovascular system. CBD has direct actions on isolated arteries, causing both acute and time-dependent reduction of vessel walls."   How does CBD work in heart disease? It reduces inflammation, reduces anxiety, aids steep, lowers blood sugar, aids detoxification, among other functions.   What is a typical therapeutic dose? Oral anywhere between 20 to 300 mg, one to three times daily.   Are there any side effects? Yes, dizziness is the most common effect. While its a powerful anti-depressant, depression is reported in some cases.     Can you overdose on CBD. Yes, but death from CBD overdose is approximately zero.     Is CBD safe? CBD is exceptionally safe.  Though it is definitely not recommended, 3000 mg have been administered in clinical settings without adverse reaction. CBD is declared to be or appear exceptionally safe in literally every medical study or research group.  CBD health care professional's consensus opinion is - CBD has no potential for addiction.  THC can be weakly addictive, less than caffeine, nicotine, opiates, amphetamines.   CBD with THC is used by caregivers in Compassion Clubs as a way to wean patients off hard drugs. It works.  CBD use is associated with a reduction in cigarette, alcohol consumption and hard drug use.   Are there any instances of malpractice from recommending CBD? No.  at the date of this report, according to a detailed literature search.   Can CBD get you high? No.  In fact, CBD can stop THC induced psychosis.   What are the effects of CBD on the cardiovascular system? CBD suppresses exercise induced and other types of cardiac arrhythmias (irregular heartbeat) and reduces infarct size (heart damage) when given at reperfusion (restoration of blood flow).   CBD attenuates (lowers) cardiac dysfunction, oxidative stress (increases blood flow), fibrosis (scar tissue), inflammation and balances cell death signaling pathways in diabetic cardiomyopathy (a blood sugar disorder affecting heart function). Endocannabinoids (the body's own) acting at cannabinoid-1 receptors (found throughout the cells in the entire body) regulate cardiovascular function in hypertension.  CBD is useful to treat endocannabinoid deficiency. CBD protects against Doxorubicin (drug)-Induced Cardiomyopathy (diseased heart muscle) by Modulating (assisting) Mitochondrial (energy) Function and Biogenesis (tissue repair and growth).   What forms do CBD come in? Marijuana and hemp, oil, creams, capsules, patches, edibles, tinctures, infusions.   Where can I buy CBD Oil? Google auto results here     Does CBD harm the liver? No.  Infact, CBD use is associated with a reduction of diseases of the liver, including bile flow. CBD has shown to protect the liver from alcohol induced damage.  Liver disease contributes to cardiovascular disease.     How much should I pay for CBD products? Check around.  Don't buy anything without a laboratory certificate of analysis. Weedmaps - Price comparison   What should I look for in a CBD product? A certificate of analysis that shows the CBD content and the presence or absence of THC.   To learn more about Cannabis Based Medicines and Cardiovascular disease, click..... 420EvaluationsOnline:  Though CBD from hemp is legal, If you want to buy CBD from licensed dispensaries, cannabis clubs, marijuana clinics,  and cooperatives, you're going to need a medical marijuana 420 recommendation.   Our Telehealth process takes less than 15 minutes, documents are approved same day.  Everything is done completed 100% online and is in compliance with the guidelines provided by the Medical Board of California.   FURTHER READING Is the cardiovascular system a therapeutic target for cannabidiol? "Preclinical data appear to support a positive role for CBD treatment in the heart, and in peripheral and cerebral vasculature.  Cannabidiol (CBD) has beneficial effects in disorders as wide ranging as diabetes, Huntington's disease, cancer and colitis. Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system. CBD has direct actions on isolated arteries, causing both acute and time-dependent vasorelaxation."   Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system. CBD has direct actions on isolated arteries Br J Clin Pharmacol. 2013 Feb; 75(2): 313–322. - Published online 2012 Jun 1. doi:  10.1111/j.1365-2125.2012.04351.x   ATHEROSCLEROSIS & MEDICAL MARIJUANA “A single ultra low dose of THC before ischemia [Insufficient Blood flow] is a safe and effective treatment that reduces myocardial ischemic [Heart Attack] damage.”  Felsenstein Medical Research Center, Israel   Hardening of the arteries or Arteriosclerosis occurs when vessels become rigid and thick. Arteries are damaged -  through the aging process.     HIGH BLOOD PRESSURE & MEDICAL MARIJUANA "One way to get high blood pressure is to go mountain climbing over molehills." High blood pressure or Hypertension is a common condition where blood flows through arteries at a higher than normal pressure.  Normal blood pressure is 120 +/- 20 (pulse) and 75  +/-  mmHg (no pulse).  People with blood pressure readings above 140/90 are in danger and should be evaluated by a health professional.   "Marijuana Cannabinoids has been found to reduce inflammation of blood vessel lining which widens the pipes and lowers pressure."  Dr. W. Rivers   CBD  - The Best Possible Technical Report - VID - RECOMMENDED !!! Dr Chris Shade has done it again!!   Amazing information, which excites me no end. I plan on starting a CBD protocol alongside the Quicksilver products that are mentioned to compliment the CBD healing.      

WHY YOU'RE PROBABLY SMOKING THE WRONG STRAIN

"Most Veteran Pot smokers think they know a lot about their weed, Not true, suggests our not so small unofficial survey of doctors, patients and recreational cannabis smokers."  420EvaluationsOnline    We'll start with the TAKEAWAY, the goods in a nut-shell.   With the approval of your favorite medical professional, most everyone that medicate with cannabis should do the following: Buy marijuana with a certificate of analysis Try raw cannabis and hemp juicing Try High THCV, THC:CBD balanced, and CBD high strains Don't bother to figure out cause and effect without valid lab testing results Try medicating both orally and by vape with all forms of medication Keep it simple, use your god given common sense   This article is focused on providing a simple understanding about cannabis.  We're going to skip over the science and simple things up, so the message comes through loud and clear.  And what is the message?  Few people, including the average self anointed guru and veteran pothead really know what they're doing. Let's start with the fundamentals.   Most people are only vaguely aware of what a cannabinoid profile is, or even what a cannabinoid is.  A cannabinoid is simply a substance that activates certain body receptors to control mood, pain, neuromuscular activity, appetite, immune response, and more. The takeaway here is that the different cannabinoids in marijuana can work very differently.   One type of THC (V) for example causes the munchies, and another suppresses appetite and energises.  THCV is high in but a few strains and is obviously the preferred medication, that is if you want to get something done.  On the other hand, near bedtime and you've got pain to kill, the more sedating THC is what you want.   CANNABINOID PROFILE - A MUST - DON'T BUY WEED WITHOUT IT What is a cannabinoid profile?  A cannabinoid profile is a laboratory test that measures of each of the receptor controlling compounds in cannabis.  Unfortunately, most major dispensaries and suppliers are guilty of baffling you with bullshit.  Too often, they'll skimp on testing to save a buck, and refer to a similar strain that was tested at some point in the past.   On the various web sites, if you look close, they don't tell you what's in your bud.  What you want to do, is to ask suppliers for a certificate of analysis.  If they stonewall you, move on to another supplier and even blog about your experience.  If a supplier tells you the truth, and says that we've tested the THC content, but other cannabinoids are assumed (from testing by others on a given strain), then maybe you can give this bunch a break, that is if you find their product to be good stuff. 420EvaluarionsOnline: Clients please note, you don't pay unless approved. To access lab tested medical marijuana strains in California and Nevada, patients need a licensed doctor's recommendation.  Thanks to the Medical Board of California, 420 physician evaluations for MMJ can be done 100% online using Telemedicine  This process is fast is usually much cheaper than a visit to a doctor's office or clinic.  Click here to get started.     "The biggest problem with self anointed cannabis experts and veterans; they have a gaping hole in their methodology, they fail to firmly establish what is in their weed, and this information is too often based on heresay and inappropriate interpretation of lab test results."  W Reeves - Analytical Chemist   EXAMPLE STRAINS - THEIR CANNABINOID PROFILE & CHARACTER High THCV strains - a must to try; for those who don't like mind numbing pot and have anxiety issues.  South African strains tend to contain more THCV than average. Pineapple Purps and Doug's Varin are somewhat rare sativa-dominant variety high in THCV. THCV, a compound known to block panic attacks, reduces tremors, and suppresses appetite.  Most varieties of marijuana have the THCV bred out of it, so if you are prone to paranoia and anxiety attacks, but like the medical results that marijuana brings, this type of strain should be at top of your to-do list for marijuana., is typically only found in trace amounts in most cannabis, but Pineapple Purps is a special variety that can express a THC:THCV ratio of 3:1. This strain is still highly psychoactive but energetic, effects are shorter lived, so patients should consider dosing with edibles or capsules for longer lasting relief.   Pineapple Purps Basic Cannabinoid Profile THC 12% THCV  4% CBD 0.2% Other cannabinoids and terpenes: See Lesson #2 Doug’s Varin is another rare sativa that was bred for high THCV, a psychoactive cannabis compound that has anti-anxiety, anti-tremor, anti-appetite, energising properties.  Strangely, the outstanding properties of this strain should be in great demand, but for some reason, it's hard to get high THCV strains today.   These high THCV strains are also high terpene strains.  How can you tell?  Terpenes are strongly aromatic and evaporate.  They are easily detected by the nose, smelling of pineapple, pine, citrus, mint and even petroleum.     Trichomes, where the bulk of the cannabinoids, THC, THCV, CBD, and terpenes reside.   High CBD Strains Anyone that uses cannabis has to try either CBD with THC or high CBD strains and compare it with their mono-THC strain experience.  CBD is non-psychoactive and is known for its pain, relief anti-inflammatory, anti-epileptic, bone mending, anti-nausea properties.  The average person finds marijuana with equal quantities of both CBD and THC to be greatly preferable to THC only strains.  It's the difference between feeling happy and just plain weirdo.     Must Try Example 1:1 CBD:THC Strain Mango Haze 14% THC and 16% CBD Effects: Highly medicinal, psychoactive relaxing, happy,a night weed   Must Try Example mono-CBD Example Strain, Charlotte's Web 0.3% THC and 15-20% CBD Effects: Non-intoxicating, relaxing, highly medicinal for some conditions Warning: High doses of CBD makes some people dizzy.  Start slow   FOOD FOR THOUGHT CBD might work best with a little bit of THC, rather than near zero.   High CBD weed can be cut with high THC weed to achieve a 1:1 ration It would be interesting to find a strain high in both CBD and THCV, as their properties suggest possible the highest balanced, happy medicinal experience?  Medical researchers could cut Charlotte's Web with Doug’s Varin and achieve a ratio of roughly 1:1:1 THC:CBD:THCV.  We'd love to see what the results of that clinical trial.   MOST STRAINS ARE NOT AS MEDICINAL AS THEY COULD BE Common marijuana strains are predominantly high in THC and little else.  Until recently, the evolution of most marijuana western strains was in the hands of, can we say potheads?  Pothead is defined as a person that loves his dope, strong (THC) and often.  While marijuana is not less addictive than alcohol, nicotine, caffeine and hard drugs, pot heads are well known for medicating.  Unfortunately, most strains out there cater to a minority of people that can tolerate THC well, and have subsequently smoked so much that they crave a dose that puts the average flat on their back.   WEED CBD & THC = SUPERIOR MEDICINE & BETTER HIGH This crowd of outliers are in their own biochemical category.  Anyone who enjoys strong weed, with 20+% THC is capable of "handling" high doses of the psychoactive compound.  However, their preferred dose is neither desirable nor recommended to the general population.  The rate of interaction of THC with the receptors, (CB1 in particular) can vary by ten times or even more.  While the LD50 (lethal dose) is so low that physiological damage is impossible in practice, the super potent mono-strains of THC are not palatable, don't deliver either a superior recreational nor medicinal experience.   420EvaluationsOnline:  Our 420 recommendations, Cannabis ID Cards, and Grower's permits are accepted at all licensed dispensaries, delivery services, online suppliers, clinics and cannabis clubs in California and most of Nevada.   FURTHER READING Females Build Up Tolerance To Marijuana Faster Than Males, Study Finds Interesting study, but take the results with a grain of salt, unless you are a female RAT, because experiments are done on female RATS.   “It’s not entirely predictive, but if you become rapidly tolerant to a drug, you may be at greater risk for developing an addiction,” Professor Rebecca Craft CBD Strains - A Vast Selection at Leafly A comprehensive list of CBD strains, however, in too many cases, valid laboratory analysis of the cannabinoids is sorely needed. What are Cannabinoids Cannabinoids are the compounds that make up the cannabis plant, with THC and CBD being the hot ones right now...scientists have now found over 120 different cannabinoids in the cannabis plant and are finding more each day....because research has been denied on this plant, we are only now able to do research ...   Cannabinoid and Terpene Testing at SteepHill Lab Below, find a cannabinoid and terpene profile of a medical marijuana strain called Pineapple Purps.  Basically, you have a high THCV strain with interesting bonus terpene values.  If you try Pineapple Purps and don't feel energised, then we ask, did you look at a valid certificate of analysis?

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